Title
Analiza hemijskog sastava i biološke aktivnosti sekundarnih metabolita biljne vrste Barbarea vulgaris (Brassicaceae)
Creator
Gusinac, Amina,
CONOR:
88531721
Copyright date
2025
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 19.03.2026.
Other responsibilities
University
Univerzitet u Nišu
Faculty
Prirodno-matematički fakultet
Group
Odsek za hemiju
Alternative title
Analysis of the chemical composition and biological activity of Barbarea vulgaris (Brassicaceae)
Publisher
[A. M. Gusinac]
Format
172 listova
description
Biografija: list. 170.
Bibliografija: list. 171-172.
description
Organic chemistry and biochemistry, organic synthesis
Abstract (en)
The doctoral dissertation is focused on investigating the phytochemical
composition of Barbarea vulgaris from Serbia, a member of the
Brassicaceae family known for its remarkable intraspecific chemical
variability. Although this species has previously been the subject of
numerous studies, populations from our region remain insufficiently
described, which highlights the importance of this research within the
broader context of phytochemistry and chemotaxonomy. Special
emphasis is placed on glucosinolates – metabolites essential in plant
defense, recognized as a potential source of pharmaceutically and
nutritionally valuable compounds.
The research includes the isolation and analysis of essential oil and
autolysates of B. vulgaris, identification of glucosinolate degradation
products, as well as the isolation or synthesis of selected compounds
for their chemical and biological characterization. Using modern
analytical techniques (GC-FID, GC-MS, NMR, UV-Vis, IR) in
combination with biological assays, the antimicrobial, antiinflammatory,
and antioxidant properties of the obtained molecules were evaluated.
The scientific contribution of this work lies in expanding the
knowledge of chemical variability within local populations of B.
vulgaris, identifying potentially new chemotypes, and obtaining
compounds that may serve as a basis for the development of new
bioactive agents.
Authors Key words
organska hemija i biohemija, organske sinteze
Authors Key words
organic chemistry and biochemistry, organic synthesis
Classification
581.192:[582.683.2:577.121](043.3)
Subject
P 003; P 004; P 300; P 390
Type
Tekst
Abstract (en)
The doctoral dissertation is focused on investigating the phytochemical
composition of Barbarea vulgaris from Serbia, a member of the
Brassicaceae family known for its remarkable intraspecific chemical
variability. Although this species has previously been the subject of
numerous studies, populations from our region remain insufficiently
described, which highlights the importance of this research within the
broader context of phytochemistry and chemotaxonomy. Special
emphasis is placed on glucosinolates – metabolites essential in plant
defense, recognized as a potential source of pharmaceutically and
nutritionally valuable compounds.
The research includes the isolation and analysis of essential oil and
autolysates of B. vulgaris, identification of glucosinolate degradation
products, as well as the isolation or synthesis of selected compounds
for their chemical and biological characterization. Using modern
analytical techniques (GC-FID, GC-MS, NMR, UV-Vis, IR) in
combination with biological assays, the antimicrobial, antiinflammatory,
and antioxidant properties of the obtained molecules were evaluated.
The scientific contribution of this work lies in expanding the
knowledge of chemical variability within local populations of B.
vulgaris, identifying potentially new chemotypes, and obtaining
compounds that may serve as a basis for the development of new
bioactive agents.
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