The relationship of dermoscopic characteristics of cutaneous metastases with pathohistological parametres of primary tumor and clinical characteristics of melanoma patients

[D. D. Popović]

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Biografija kandidata: list 184 Bibliografija: list. 155-183

Dermatovenerology, Pathology

This scientific research aims to determine both clinical and dermoscopic characteristics of cutaneous metastases in patients with primary cutaneous melanoma. Methodology: The dissertation examines the association of dermoscopic characteristics of cutaneous metastases with the characteristics of primary melanoma, its histopathological features and localization, as well as the clinical characteristics of melanoma patients monitored after surgery at the Clinic for Dermatovenereology of the University Clinical Center Niš, the Clinic for Oncology of the University Clinical Center Niš, and the Clinic for Skin and Venereal Diseases of the Military Medical Academy in Belgrade, in the period from 2020 to 2024. Dermoscopic patterns of cutaneous metastases were analyzed. Additionally, the types of structural patterns, additional dermoscopic characteristics, and the dominant colour were determined. The relationships between the examined parameters were examined using statistical data processing. Significance of the research: The majority of cutaneous melanoma metastases had a homogeneous pattern (43.8%), followed by a vascular (33.8%), saccular (12.5%), and polymorphic (10%) one. The frequency of dermoscopic pattern types varied across different clinical types of cutaneous melanoma metastases (flat and elevated) and between pigmented and non-pigmented lesions. Flat cutaneous metastases (macules) predominantly have a homogeneous pattern (72.7%), while elevated cutaneous metastases (papules and nodules) most often have a vascular pattern (39.7%); the homogeneous pattern is dominant (65.3%) in pigmented cutaneous metastases, while the vascular pattern prevails (87.5%) in non-pigmented ones. The type of dermoscopic pattern varies according to the type of primary cutaneous melanoma. In nodular melanoma, the prevailing patterns in its cutaneous metastases are the homogeneous (46.3%) and vascular (36.6%) ones, while in acral lentiginous melanoma, the vascular pattern of cutaneous metastases is the most frequent (50%). The presence of additional dermoscopic characteristics is significantly more common in elevated than in flat cutaneous metastases. Non-pigmented cutaneous metastases show a significantly higher frequency of blood vessels (96.8%) compared with the pigmented ones (32.7%). Mitoses were significantly more frequent in the histopathological findings of primary melanoma in non-pigmented cutaneous metastases. In non-pigmented melanoma metastases, the predominant colour is red (77.4%), while in the pigmented ones, it is blue (51%) and brown (34.7%).

kutane metastaze melanoma, melanom, dermoskopske karakteristike, koža

Cutaneous melanoma metastases, melanoma, dermoscopic characteristics, skin

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