Title
Efekat i sinergičko dejstvo etarskih ulja odabranih aromatičnih i lekovitih biljnih vrsta na rast i faktore virulencije izolata roda candida
Creator
Dimitrijević, Marina V., 1992-
CONOR:
135044361
Copyright date
2025
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 25.11.2025.
Other responsibilities
University
Univerzitet u Nišu
Faculty
Prirodno-matematički fakultet
Group
Odsek za biologiju i ekologiju
Alternative title
Effect and synergistic action of selected aromatic and medicinal plants essential oils on the growth and virulence factors of candida isolates
Publisher
[M. V. Dimitrijević]
Format
174 list.
description
Biografija sa [personal.] bibliografijom: str. 164-171.
Bibliografija: str. 121-163.
description
Microbiology
Abstract (en)
In this doctoral dissertation, the antifungal activity of essential oils derived
from plant species belonging to the families Lamiaceae (Satureja montana,
Thymus vulgaris, Origanum vulgare), Asteraceae (Inula helenium,
Helichrysum italicum), and Rutaceae (Citrus aurantium, Citrus aurantifolia,
Citrus limon, Citrus paradisi) was investigated, with the aim of identifying
potential new agents for the treatment of candidоsis. Experiments were
conducted on two sets of human clinical Candida isolates: the first set
consisted of isolates from various infections, while the second set included
vulvovaginal isolates.
The study examined the antifungal and antivirulence potential of the oils,
including antibiofilm activity, inhibition of germ tube formation, reduction of
phospholipase production, as well as their interactions with nystatin and the
mutual interactions between individual oils.
Chemical composition analysis was performed, and minimal inhibitory
concentrations (MICs) were determined, revealing significant anti-Candida
activity: 0.312–2.500 mg/mL (Lamiaceae), 0.009–5.00 mg/mL (Asteraceae),
and 0.009–10.00 mg/mL (Rutaceae). The oils demonstrated the ability to
reduce biofilm formation at MIC and ½ MIC. The highest activity against the
first set of isolates was shown by I. helenium oil, while C. aurantium oil
exhibited the greatest efficacy against the second set. Both oils significantly
reduced germ tube formation and phospholipase production, indicating a
pronounced antivirulence potential.
These findings contribute to a better understanding of essential oils’ effect
against human clinical Candida isolates and their capacity to reduce
virulence factors, highlighting the possibility of their application as adjunctive
therapy for candidоsis.
Authors Key words
Candida albicans, Candida krusei, etarska ulja, Lamiaceae, Asteraceae,
Rutaceae, hemijski sastav, sinergizam, faktori virulencije
Authors Key words
Candida albicans, Candida krusei, essential oils, Lamiaceae, Asteraceae,
Rutaceae, chemical composition, synergism, virulence factors
Classification
633.81+547.913]:[579.6+615.282.84(043.3);
633.88+547.913]:[579.6+615.282.84(043.3)
Subject
В 230
Type
Tekst
Abstract (en)
In this doctoral dissertation, the antifungal activity of essential oils derived
from plant species belonging to the families Lamiaceae (Satureja montana,
Thymus vulgaris, Origanum vulgare), Asteraceae (Inula helenium,
Helichrysum italicum), and Rutaceae (Citrus aurantium, Citrus aurantifolia,
Citrus limon, Citrus paradisi) was investigated, with the aim of identifying
potential new agents for the treatment of candidоsis. Experiments were
conducted on two sets of human clinical Candida isolates: the first set
consisted of isolates from various infections, while the second set included
vulvovaginal isolates.
The study examined the antifungal and antivirulence potential of the oils,
including antibiofilm activity, inhibition of germ tube formation, reduction of
phospholipase production, as well as their interactions with nystatin and the
mutual interactions between individual oils.
Chemical composition analysis was performed, and minimal inhibitory
concentrations (MICs) were determined, revealing significant anti-Candida
activity: 0.312–2.500 mg/mL (Lamiaceae), 0.009–5.00 mg/mL (Asteraceae),
and 0.009–10.00 mg/mL (Rutaceae). The oils demonstrated the ability to
reduce biofilm formation at MIC and ½ MIC. The highest activity against the
first set of isolates was shown by I. helenium oil, while C. aurantium oil
exhibited the greatest efficacy against the second set. Both oils significantly
reduced germ tube formation and phospholipase production, indicating a
pronounced antivirulence potential.
These findings contribute to a better understanding of essential oils’ effect
against human clinical Candida isolates and their capacity to reduce
virulence factors, highlighting the possibility of their application as adjunctive
therapy for candidоsis.
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