Title
Sekundarni metaboliti odabranih vrsta jetrenjača rodova Porella L. (PORELLACEAE) i conocephalum HILL. (CONOCEPHALACEAE)
Creator
Filipović, Sonja I.
CONOR:
82693641
Copyright date
2025
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 02.07.2025.
Other responsibilities
University
Univerzitet u Nišu
Faculty
Prirodno-matematički fakultet
Group
Odsek za hemiju
Alternative title
Secondary metabolites of selected liverworts from the genera porella L. (PORELLACEAE) and conocephalum HILL. (CONOCEPHALACEAE)
Publisher
[S. I. Filipović]
Format
393 str.
description
Bibliografija: str. 270-308.
description
Organic and medicinal chemistry, biochemistry
Abstract (en)
In this doctoral dissertation, the chemical composition of essential oils and extracts from three liverworts, two species from the Porellaceae family (Porella platyphylla and Porella cordaeana), as well as the species Conocephalum conicum from the Conocephalaceae family, was investigated. The essential oils were obtained by hydrodistillation, and their analysis was performed by GC-MS. Preparative chromatographic separations of the essential oils and extracts led to the isolation of pure compounds, whose structures were determined by combining spectral methods (1D- and 2D-NMR, GC-MS, FTIR, HRMS, etc.) and chemical transformations. Special attention was given to new natural products, including two derivatives of the pinguisanе skeleton (α-furanopinguisanol and furanopinguisanone), a compound of the lepidozane skeleton ((1Z,4E)-lepidoza-1(10),4-dien-14-ol), and a sesquiterpene diol of the germacrane skeleton with the structure rel-(1(10)Z,4S,5E,7R)-germacra-1(10),5-dien-11,14-diol. Detailed analysis of the NMR spectra identified another new compound, rel-(1(10)Z,4S,5E,7R)-humula-1(10),5-dien-7,14-diol. The biological activity and pharmacological potential of selected secondary metabolites were investigated by various methods on rat lymphocytes.
Authors Key words
jetrenjača, Porella platyphylla, Porella cordaeana, Conocephalum conicum, etarsko ulje, hromatografija, pingvizani, lepidozani, germakrani, humulani, sinteza, (bio)hemijska povezanost, biološka/farmakološka aktivnost
Authors Key words
liverwort, Porella platyphylla, Porella cordaeana, Conocephalum conicum, essential oil, chromatography, pinguisanes, lepidozanes, germacranes, humulanes, synthesis, (bio)chemical connection, biological/pharmacological activity
Classification
577.121:582.321.1(043.3)
Subject
P 003, P 390, P 351, P 004
Type
Tekst
Abstract (en)
In this doctoral dissertation, the chemical composition of essential oils and extracts from three liverworts, two species from the Porellaceae family (Porella platyphylla and Porella cordaeana), as well as the species Conocephalum conicum from the Conocephalaceae family, was investigated. The essential oils were obtained by hydrodistillation, and their analysis was performed by GC-MS. Preparative chromatographic separations of the essential oils and extracts led to the isolation of pure compounds, whose structures were determined by combining spectral methods (1D- and 2D-NMR, GC-MS, FTIR, HRMS, etc.) and chemical transformations. Special attention was given to new natural products, including two derivatives of the pinguisanе skeleton (α-furanopinguisanol and furanopinguisanone), a compound of the lepidozane skeleton ((1Z,4E)-lepidoza-1(10),4-dien-14-ol), and a sesquiterpene diol of the germacrane skeleton with the structure rel-(1(10)Z,4S,5E,7R)-germacra-1(10),5-dien-11,14-diol. Detailed analysis of the NMR spectra identified another new compound, rel-(1(10)Z,4S,5E,7R)-humula-1(10),5-dien-7,14-diol. The biological activity and pharmacological potential of selected secondary metabolites were investigated by various methods on rat lymphocytes.
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