Title
Molekularni mehanizmi ishemijsko-reperfuzionog oštećenja tokom resekcije jetre
Creator
Gmijović, Marko, 1984-
CONOR:
37748327
Copyright date
2024
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 12.6.2024.
Other responsibilities
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za hirurgiju
Alternative title
Molecular mechanisms of hepatic ischemia - reperfusion injury during resection procedures
Publisher
[M. Gmijović]
Format
127 listova
description
Biografija autora: list 124
Bibliografija: list. 115-122
description
Surgery, general surgery
Abstract (en)
Introduction: Bleeding during liver resection is a significant threat to the clinical outcome. The occlusion of the portal triad, inducing complete ischemia of the blood supply to the liver, is a well-documented, safe, and beneficial method for alleviating this problem. Although this technique is effective in limiting blood loss, there are still controversies regarding the potential drawbacks of ischemia and subsequent reperfusion injury to liver tissue. Material and Methods: The prospective study included 30 patients, average age of 62 years, who underwent liver resection surgery due to the neoplastic process or metastases of colorectal cancer. After obtaining informed consent, parameters were analyzed in three phases: preoperative, intraoperative, and postoperative. During the surgery (recommended by the surgeon/oncology board independent of our study), samples of "conditionally healthy liver tissue" (not affected by tumor processes) were taken. Following tissue homogenization, parameters responsible for the onset of liver tissue damage due to ischemia-reperfusion injury (IRI) were analyzed.
Ethical standards: Based on the research findings, there were no direct influences noticed on the current clinical procedures, treatment processes, or the final treatment outcome among the patients involved in the study. Nevertheless, the insights obtained from this research may be beneficial for planning and conducting future liver resections in new patients. The analyses derived from this research could offer valuable guidelines for enhancing postoperative care and better understanding the factors impacting patient recovery after resection procedures.
Conclusion: Using modern research methods, scientifically validated statistical data analysis, and appropriate literature, significant data about the nature or
Authors Key words
Resekcije jetre, transplantacije jetre, ishemijsko reperfuziono oštećenje, metastaze kolorektalnog karcinoma, karcinom jetre, apoptoza, vaskularna izolacija jetre.
Authors Key words
liver resections, liver transplantations, ischemia-reperfusion injury, metastases of colorectal carcinoma, liver cancer, apoptosis, hepatic vascular isolation.
Classification
616.36-006.6-089(043.3)
Subject
B 600
Type
Tekst
Abstract (en)
Introduction: Bleeding during liver resection is a significant threat to the clinical outcome. The occlusion of the portal triad, inducing complete ischemia of the blood supply to the liver, is a well-documented, safe, and beneficial method for alleviating this problem. Although this technique is effective in limiting blood loss, there are still controversies regarding the potential drawbacks of ischemia and subsequent reperfusion injury to liver tissue. Material and Methods: The prospective study included 30 patients, average age of 62 years, who underwent liver resection surgery due to the neoplastic process or metastases of colorectal cancer. After obtaining informed consent, parameters were analyzed in three phases: preoperative, intraoperative, and postoperative. During the surgery (recommended by the surgeon/oncology board independent of our study), samples of "conditionally healthy liver tissue" (not affected by tumor processes) were taken. Following tissue homogenization, parameters responsible for the onset of liver tissue damage due to ischemia-reperfusion injury (IRI) were analyzed.
Ethical standards: Based on the research findings, there were no direct influences noticed on the current clinical procedures, treatment processes, or the final treatment outcome among the patients involved in the study. Nevertheless, the insights obtained from this research may be beneficial for planning and conducting future liver resections in new patients. The analyses derived from this research could offer valuable guidelines for enhancing postoperative care and better understanding the factors impacting patient recovery after resection procedures.
Conclusion: Using modern research methods, scientifically validated statistical data analysis, and appropriate literature, significant data about the nature or
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