Title
Komparativna analiza imunskog odgovora i oksidativnog stresa kod pacijenata sa psorijazom i atopijskim dermatitisom
Creator
Bakić, Mirjana 1976-
CONOR:
900455
Copyright date
2023
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 04.03.2024.
Other responsibilities
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za dermatovenerologiju
Alternative title
Comparative analysis of immune response and oxidative stress in patients with psoriasis and atopic dermatitis
Publisher
[M. Bakić]
Format
122 [2] str.
description
Biografija autora: str. [2].
Bibliografija: str. 103-122.
description
Dermatovenerology
Abstract (en)
Aim: Psoriasis (PsO) and atopic dermatitis (AD) are chronic
inflammatory, immune-mediated diseases characterized by activation
of Th22 T-cells and the Th1 pathway with increased production of IL-
22 and IFN-γ. Oxidative stress plays a significant role in the
pathogenesis of PsO and AD. Therefore, the aim of our research was
to perform a comparative analysis of the immune response of
cytokines, protein and non-protein mediators of inflammation and
oxidative stress for both diseases. In line with this, we investigated the
possibility of detecting a sufficiently sensitive and specific biomarker
that could indicate the presence of one of the two pathophysiological
entities that are the subject of this research, as well as the detection of
a biomarker or a group of biomarkers (models) that would enable the
prediction of the presence of comorbidities in certain patients, and the
prediction of high values of the severity of the clinical picture in
psoriasis, as well as the impact on the quality of life of patients affected
by psoriasis and atopic dermatitis. Methodology: Eighty patients
underwent anthropometric measurements, evaluation of the severity of
the clinical picture, as well as blood sampling for biochemical and
hematological analyzes, on the basis of which cellular parameters and
indices of immune response activation, acute phase proteins, cytokines
IL-22 and IFN-γ, markers of oxidative stress, as well as markers of
systemic inflammation were determined. Results: Catalase enzyme
was detected as a marker for distinguishing between psoriasis and
atopic dermatitis. The antioxidant score showed diagnostic accuracy in
predicting the risk values of the severity of the clinical picture of
psoriasis and the impact on the quality of life. Certain groups of
biomarkers were detected as predictors of the type of disease,
predictors of the presence of comorbidities, as well as predictors of
high values of the quality of life index of the examined
patients.Conclusion: Our results indicate that catalase enzyme has
good diagnostic accuracy in separating patients with AD from patients
with PsO. Also, biomarkers were detected as predictors of the type of
disease, comorbidity, and high values of the quality of life index of
patients in both diseases. No statistically significant difference was
found in the concentration of the inflammation marker, CRP, new
inflammatory indices derived from hematological parameters (NLR
and Tr/Ly ratio), and immune markers, IFN-γ and IL-22.
Further longitudinal studies involving a greater number of subjects are
needed to confirm our results and determine the most reliable
diagnostic and prognostic biomarkers for PsO and AD.
Authors Key words
psorijaza, atopijski dermatitis, inflamacija, oksidativni
stres, citokini
Authors Key words
psoriasis, Atopic dermatitis, inflammation, oxidative stress, cytokines
Classification
616.5-097:577.1(043.3)
Subject
B 630
Type
Tekst
Abstract (en)
Aim: Psoriasis (PsO) and atopic dermatitis (AD) are chronic
inflammatory, immune-mediated diseases characterized by activation
of Th22 T-cells and the Th1 pathway with increased production of IL-
22 and IFN-γ. Oxidative stress plays a significant role in the
pathogenesis of PsO and AD. Therefore, the aim of our research was
to perform a comparative analysis of the immune response of
cytokines, protein and non-protein mediators of inflammation and
oxidative stress for both diseases. In line with this, we investigated the
possibility of detecting a sufficiently sensitive and specific biomarker
that could indicate the presence of one of the two pathophysiological
entities that are the subject of this research, as well as the detection of
a biomarker or a group of biomarkers (models) that would enable the
prediction of the presence of comorbidities in certain patients, and the
prediction of high values of the severity of the clinical picture in
psoriasis, as well as the impact on the quality of life of patients affected
by psoriasis and atopic dermatitis. Methodology: Eighty patients
underwent anthropometric measurements, evaluation of the severity of
the clinical picture, as well as blood sampling for biochemical and
hematological analyzes, on the basis of which cellular parameters and
indices of immune response activation, acute phase proteins, cytokines
IL-22 and IFN-γ, markers of oxidative stress, as well as markers of
systemic inflammation were determined. Results: Catalase enzyme
was detected as a marker for distinguishing between psoriasis and
atopic dermatitis. The antioxidant score showed diagnostic accuracy in
predicting the risk values of the severity of the clinical picture of
psoriasis and the impact on the quality of life. Certain groups of
biomarkers were detected as predictors of the type of disease,
predictors of the presence of comorbidities, as well as predictors of
high values of the quality of life index of the examined
patients.Conclusion: Our results indicate that catalase enzyme has
good diagnostic accuracy in separating patients with AD from patients
with PsO. Also, biomarkers were detected as predictors of the type of
disease, comorbidity, and high values of the quality of life index of
patients in both diseases. No statistically significant difference was
found in the concentration of the inflammation marker, CRP, new
inflammatory indices derived from hematological parameters (NLR
and Tr/Ly ratio), and immune markers, IFN-γ and IL-22.
Further longitudinal studies involving a greater number of subjects are
needed to confirm our results and determine the most reliable
diagnostic and prognostic biomarkers for PsO and AD.
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