Title
Značaj ekspresije markera hipoksije i neoangiogeneze u praćenju pacijenata sa urotelnim karcinomom mokraćne bešike
Creator
Ristić, Ana, 1980-
CONOR:
8681319
Copyright date
2022
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 26.12.2022.
Other responsibilities
predsednik komisije
Jovičič-Milentijević , Maja
član komisije
Radojević-Škodrić, Sanja
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za patologiju
Alternative title
The significance of the hypoxia-related and neoangiogenesis marker expression in the urothelial bladder cancer
Publisher
[A. V. Ristić Petrović]
Format
[8], 141 list
description
Biografija autora: list: 141,
Bibliografija: listovi 119-136
description
Pathology
Abstract (en)
The most common type of bladder cancer, in over 90% of cases, is urothelial bladder cancer. Seven out of ten cases of urothelial bladder cancer are detected at an early stage. Approximately 70-80% of newly diagnosed present with noninvasive (pTa and pTis stages) or early invasive tumors (pT1 stage). Relapses are frequent and occur in 50-70% of cases, while progression to muscle-invasive (pT2 stage) occurs in 15-25% of cases. In this study, the expression of HIF1α, VEGF, VEGFR1, NOTCH3, JAGGED1, and morphometrically determined density of CD34 positive micro-vessels (MVD) on 613 urothelial bladder cancer samples were immunohistochemically examined. Their interrelationship, as well as, the relationship with clinical-pathological parameters and patient survival were analyzed. The presented study identified HIF1α, VEGFR1, NOTCH3 and MVD as independent prognostic parameters for overall survival and bladder cancer specific patient survival. Positive expression of NOTCH3, higher density of micro-vessels (MVD) and absence of expression of HIF1α and VEGFR1 indicate shorter overall and cancer-specific survival. Molecular participants in HIF1α, VEGF and NOTCH signaling pathways and their detection in tissue show a strong influence of hypoxia and angiogenesis in the formation of more invasive bladder cancer clones. The prognostic value of these markers in the monitoring of bladder cancer patients is great and can contribute to a more individual approach when deciding on further treatment, in order to delay radical cystectomy and preserve the bladder for as long as possible. The latest therapeutic modalities are based on the manipulation of the examined signaling pathways, whose ultimate goal is the introduction of personalized, targeted, molecular therapy in the treatment of urothelial bladder cancer.
Authors Key words
Urotelni karcinom mokraćne bešike, angiogeneza, hipoksija, imunohistohemija, preživljavanje, prognoza
Authors Key words
Urothelial bladder cancer, angiogenesis, hypoxia, immunohistochemistry, survival, prognosis
Classification
616.12-006.6:612.22-076(043.3)
Subject
B520
B200
Type
Tekst
Abstract (en)
The most common type of bladder cancer, in over 90% of cases, is urothelial bladder cancer. Seven out of ten cases of urothelial bladder cancer are detected at an early stage. Approximately 70-80% of newly diagnosed present with noninvasive (pTa and pTis stages) or early invasive tumors (pT1 stage). Relapses are frequent and occur in 50-70% of cases, while progression to muscle-invasive (pT2 stage) occurs in 15-25% of cases. In this study, the expression of HIF1α, VEGF, VEGFR1, NOTCH3, JAGGED1, and morphometrically determined density of CD34 positive micro-vessels (MVD) on 613 urothelial bladder cancer samples were immunohistochemically examined. Their interrelationship, as well as, the relationship with clinical-pathological parameters and patient survival were analyzed. The presented study identified HIF1α, VEGFR1, NOTCH3 and MVD as independent prognostic parameters for overall survival and bladder cancer specific patient survival. Positive expression of NOTCH3, higher density of micro-vessels (MVD) and absence of expression of HIF1α and VEGFR1 indicate shorter overall and cancer-specific survival. Molecular participants in HIF1α, VEGF and NOTCH signaling pathways and their detection in tissue show a strong influence of hypoxia and angiogenesis in the formation of more invasive bladder cancer clones. The prognostic value of these markers in the monitoring of bladder cancer patients is great and can contribute to a more individual approach when deciding on further treatment, in order to delay radical cystectomy and preserve the bladder for as long as possible. The latest therapeutic modalities are based on the manipulation of the examined signaling pathways, whose ultimate goal is the introduction of personalized, targeted, molecular therapy in the treatment of urothelial bladder cancer.
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