Title
Patofiziološki aspekti glomerulskih i tubulointesticijskih bubrežnih oboljenja: proteomski pristup : doktorska disertacija
Creator
Pešić, Ivana
Copyright date
2011
Object Links
Select license
Autorstvo-Deliti pod istim uslovima 3.0 Srbija (CC BY-SA 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
Other responsibilities
mentor
Stefanović, Vladislav
član komisije
Bojanić, Vladmila
član komisije
Stojmenov, Tatjana Jeftović
član komisije
Miler, Gerhard A.
član komisije
Dihazi, Hasan
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za patološku fiziologiju
Title translated
PATHOPHYSIOLOGY OF GLOMERULAR AND TUBULOINTERSTITIAL KIDNEY DISEASES: PROTEOMIC APPROACH
Publisher
Niš : [I. Pešić]
Format
PDF/A (131 list)
description
Umnoženo za odbranu.
Univerzitet u Nišu, Medicinski fakultet. 2011.
Bibliografija: listovi 111-126.
Sažetak ; Summary.
Abstract (en)
Introduction: Kidney diseases are the biggest health problem nowadays. Endemic
nephropathy (EN) is a chronic tubulointerstitial kidney disease, undetectable at the
beginning and with slow development to terminal renal failure. The real cause of the
disease is still not known. Although the importance of inheritance is underlined, the
effects of environmental factors (aristolochic acid, a mycotoxin) and the presence of
disorders of the immune system are more likely to be involved in disease pathway.
Aim: We aimed to establish qualitative and quantitative differences of proteins in
urine of patients with the endemic nephropathy, diabetic nephropathy, acute prerenal
kidney injury, and their importance in the diagnostics. The acute and chronic effects of
aristolochic acid 1 and ochratoxin A on tubulocytes are important for establishing the
mechanisms of kidney damage and the potential biomarkers.
Methods: Proteomic technology was used, and the results were confirmed by
Western blot, dot blot, immunofluoroscence and immunohistochemisry analyses of cells
and tissue samples.
Importance: The use of proteomic technologies of urine proteins in patients and
healthy controls gives a new data for the identification of diagnostic and prognostic
markers of kidney damage. This study shows the presence of significant differences in the
proteins of the respondents, which can be used as diagnostic and differential diagnostic
parameters. Study of toxic effects of aristolochic acid 1 and ochratoxin A permited a
better understanding of the mechanisms of kidney disease, but first of all, a better
expanation of molecular pathway in the initiation and during development of endemic
nephropathy and associated urothelial cancer.
Authors Key words
Bubrežna oboljenja, Patofiziologija
Subject
616
Type
Elektronska teza
Abstract (en)
Introduction: Kidney diseases are the biggest health problem nowadays. Endemic
nephropathy (EN) is a chronic tubulointerstitial kidney disease, undetectable at the
beginning and with slow development to terminal renal failure. The real cause of the
disease is still not known. Although the importance of inheritance is underlined, the
effects of environmental factors (aristolochic acid, a mycotoxin) and the presence of
disorders of the immune system are more likely to be involved in disease pathway.
Aim: We aimed to establish qualitative and quantitative differences of proteins in
urine of patients with the endemic nephropathy, diabetic nephropathy, acute prerenal
kidney injury, and their importance in the diagnostics. The acute and chronic effects of
aristolochic acid 1 and ochratoxin A on tubulocytes are important for establishing the
mechanisms of kidney damage and the potential biomarkers.
Methods: Proteomic technology was used, and the results were confirmed by
Western blot, dot blot, immunofluoroscence and immunohistochemisry analyses of cells
and tissue samples.
Importance: The use of proteomic technologies of urine proteins in patients and
healthy controls gives a new data for the identification of diagnostic and prognostic
markers of kidney damage. This study shows the presence of significant differences in the
proteins of the respondents, which can be used as diagnostic and differential diagnostic
parameters. Study of toxic effects of aristolochic acid 1 and ochratoxin A permited a
better understanding of the mechanisms of kidney disease, but first of all, a better
expanation of molecular pathway in the initiation and during development of endemic
nephropathy and associated urothelial cancer.
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