General Metadata
Title
Odnos heat shock proteina i markera inflamacije miokarda kod neonatusa
Creator
Mrkaić, Ana G. 1979-
Copyright date
2017
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Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
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Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
1025698541
Academic metadata
Theses Type
Doktorska disertacija
description
Datum odbrane: 02.06.2017.
Other responsibilities
mentor
Stojanović, Ivana
član komisije
Pejčić, Ljiljana
član komisije
Radovanović, Dragan
član komisije
Popović, Jasmina
član komisije
Kostić, Miloš
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za histologiju sa embriologijom
Other Theses Metadata
Abstract (en)
Neonatal heart remodeling occurs during delivery. With the hypothesis that this process does not occur in the same way in healthy pregnancies and those complicated with preeclampsia and gestational diabetes, in umbilical cord blood, using ELISA tests, troponin T and I, Glycogen Phosphorylase-BB, Hsp 27 and Hsp 70 concentrations were measured. The obtained concentrations were correlated with fetal and neonatal characteristics and pregnancy, labor and delivery characteristics. Hsp 70 is the most sensitive marker of fetal stress in pregnancies complicated with gestational diabetes, and cTnI and GP-BB in preeclamptic pregnancies. Hsp 70 and GP-BB concentrations increase with increased fetal heart rate during uterus contractions in labor. Fetal stres can be registered by high cTnI concentrations in maternal metabolic syndroms. Fetal stress as a consequence of maternal high blood pressure can be measured through high GP- BB and cTnI concentrations. Higher cTnI concentartions were found in neonates who had prolonged hospitalizations, while higher Hsp 27 concentrations were found in neonates who were hospitalized in neonatal intensive care unit. Hsp 27, Hsp 70, GP- BB, cTnT, cTnI are sensitive markers of the stress of fetal myocardium in pregnancies complicated by gestational diabetes and preeclampsia.