Title
Uticaj odabranih monoterpena na aktivnost dijagnostički značajnijih enzima u kontrolnom humanom serumu in vitro
Creator
Jelenković, Ljiljana A. 1967-
Copyright date
2016
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 29.09.2016.
Other responsibilities
mentor
Palić, Ivan 1974-
član komisije
Stankov Jovanović, Vesna 1968-
član komisije
Mitić, Violeta 1968-
član komisije
Radulović, Milanka
član komisije
Jevtović Stoimenov, Tatjana
Academic Expertise
Prirodno-matematičke nauke
Academic Title
-
University
Univerzitet u Nišu
Faculty
Prirodno-matematički fakultet
Group
Odsek za hemiju
Alternative title
Influence of selected monoterpenes on activity of diagnostically important enzymes in human serum in vitro
Publisher
[L. A. Jelenković]
Format
[9], 186 str.
description
Biografija [Ljiljane Jelenković] sa bibliografijom: str. 177-181
description
organic chemistry and biochemistry, Practical part of this doctoral thesis was done in Biochemical
laboratory of Health Center in Nis.
Abstract (en)
In order to determine the terpenes effect on enzyme activity is been studied
the impact of aqueous (prepared manually (I1) or ultrasound (I2) mixing) and
DMSO (dimethyl sulfoxide) terpenes solution (carvacrol, linalool, nerol and
geraniol) on the activity of creatine kinase, lactate dehydrogenase, alkaline
phosphatase, gamma-glutamyl transferase, aspartate aminotransferase and
alanine aminotransferase,as well as the impact of the same type of terpenes
solution (carvacrol, linalool, nerol, geraniol, β-pinene, myrcene, citral,
eucalyptol, terpineol, and eugenol) on the activity of amylase in the control
sera (with the normal (N) and increased (H) activity of the ingredients.
Measurement of activity was conducted after incubation of the serum sample
from the 10 minutes and aqueous solutions of terpenes prepared as I1 or as
I2, or solutions of terpenes in DMSO at four concentrations. All the terpenes
solutions have demonstrated that the inhibitory effect depends on various
parameters: kinds of serum (higher percentage of inhibition in N than the H
serum), the type of solvent ( the aqueous solution as I2 and DMSO solutions
showed approximately the same percentage of inhibition in both types of
serum) and way of preparing the aqueous solutions (a higher percentage of
inhibition have the aqueous solution of terpenes as I2 in N serum and as I1 in
H serum), as well as on the type of terpenes or enzymes. Statistical data
processing all terpenes solution (with the partial exception of neroli and
geraniol) confirmed the grouping or by type of serum or by type of solvent or
the method of preparation of aqueous solution.
Authors Key words
inhibicija, enzimska aktivnost, klinički enzimi, terpeni,
serum, karvakrol, linalol, nerol, geraniol
Authors Key words
inhibition, enzyme activity, clinical enzymes, terpenes, serum,
carvacrol, linalool, nerol, geraniol
Classification
547.596 : (612.128 + 612.15 +58.085)(043.3)
Type
Tekst
Abstract (en)
In order to determine the terpenes effect on enzyme activity is been studied
the impact of aqueous (prepared manually (I1) or ultrasound (I2) mixing) and
DMSO (dimethyl sulfoxide) terpenes solution (carvacrol, linalool, nerol and
geraniol) on the activity of creatine kinase, lactate dehydrogenase, alkaline
phosphatase, gamma-glutamyl transferase, aspartate aminotransferase and
alanine aminotransferase,as well as the impact of the same type of terpenes
solution (carvacrol, linalool, nerol, geraniol, β-pinene, myrcene, citral,
eucalyptol, terpineol, and eugenol) on the activity of amylase in the control
sera (with the normal (N) and increased (H) activity of the ingredients.
Measurement of activity was conducted after incubation of the serum sample
from the 10 minutes and aqueous solutions of terpenes prepared as I1 or as
I2, or solutions of terpenes in DMSO at four concentrations. All the terpenes
solutions have demonstrated that the inhibitory effect depends on various
parameters: kinds of serum (higher percentage of inhibition in N than the H
serum), the type of solvent ( the aqueous solution as I2 and DMSO solutions
showed approximately the same percentage of inhibition in both types of
serum) and way of preparing the aqueous solutions (a higher percentage of
inhibition have the aqueous solution of terpenes as I2 in N serum and as I1 in
H serum), as well as on the type of terpenes or enzymes. Statistical data
processing all terpenes solution (with the partial exception of neroli and
geraniol) confirmed the grouping or by type of serum or by type of solvent or
the method of preparation of aqueous solution.
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