Title
Evaluacija parametara miokardne funkcije u razvoju cirotične kardiomiopatije
Creator
Dinić Radović, Violeta A. 1970.
Copyright date
2016
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 16.05.2016.
Other responsibilities
mentor
Nagorni, Aleksandar
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za internu medicinu
Alternative title
Evaluation of the parameters of myocardial function in development of cirrhotic cardiomyopathy
Publisher
[V. А. Dinić Radović]
Format
124 lista
description
Beleška o autoru: list 123
description
Gastroenterology and hepatology
Abstract (en)
Backgorund/Aim. Cirrhotic cardiomyopathy (CCM) is a clinical syndrome
in liver cirrhosis (LC) patients (pts), witch is characterized by abnormal
cardiovascular (CV) response to physiologic, pathologic, or pharmacologic
stress provocation, but increased cardiac output and contractility at rest. The
aim of the study was to identify the structural and functional myocardial
changes in LC pts , by two-dimensional echocardiography (EC) Doppler
imaging evaluation in prediction of CCM. Methods. The research was
performed as a prospective, case-control study, on selected 40 pts with LC
and negative personal medical history on previous CV disease and 40 healthy
subjects as a control, from January 2012.-December 2014. year. There were
determining a significant ECG, EC and serum markers of myocardial
dysfunction of LC pts in prediction of CCM. Results. Most of the LC patients
were alcoholic one (80.0%), dominantly in Child-Pough C stage (70.0%).
The average value of QTc interval in the LC pts was significantly higher
(0.44±0.03 vs. 0.42±0.01 s; p<0.001), as well as serum brain natriuretic
peptide (BNP) level (284.61±181.44 vs. 69.41±31.08 ng/l; p<0.001) compare
to health subjects. There were strong association between serum BNP level
values in LC pts and values of : left atrial (LA) diameter (p=0.031), left
ventricular ejection fraction (LVEF) (p=0.014), pulmonary artery systolic
pressure (PASP) (p=0.000) and the presence of tricuspid valve regurgitation
(TVR) of 2+ (p=0.000), affecting its change of 41.6%. Conclusion. The
obtained results suggests that LC pts had significant ECG and EC signs for
myocardial dysfunction and the increased BNP serum level. LA diameter,
LVEF, PASP and TVR are valuable EC predictors of CCM.
Authors Key words
ciroza jetre, kardiomiopatije, ehokardiografija, BNP
Authors Key words
liver cirrhosis, cardiomyopathies, echocardiography, doppler,
natriuretic peptide, brain
Classification
616.36-004:616.127-007-07(043.3)
Subject
616.36-004
Subject
B550
Type
Elektronska teza
Abstract (en)
Backgorund/Aim. Cirrhotic cardiomyopathy (CCM) is a clinical syndrome
in liver cirrhosis (LC) patients (pts), witch is characterized by abnormal
cardiovascular (CV) response to physiologic, pathologic, or pharmacologic
stress provocation, but increased cardiac output and contractility at rest. The
aim of the study was to identify the structural and functional myocardial
changes in LC pts , by two-dimensional echocardiography (EC) Doppler
imaging evaluation in prediction of CCM. Methods. The research was
performed as a prospective, case-control study, on selected 40 pts with LC
and negative personal medical history on previous CV disease and 40 healthy
subjects as a control, from January 2012.-December 2014. year. There were
determining a significant ECG, EC and serum markers of myocardial
dysfunction of LC pts in prediction of CCM. Results. Most of the LC patients
were alcoholic one (80.0%), dominantly in Child-Pough C stage (70.0%).
The average value of QTc interval in the LC pts was significantly higher
(0.44±0.03 vs. 0.42±0.01 s; p<0.001), as well as serum brain natriuretic
peptide (BNP) level (284.61±181.44 vs. 69.41±31.08 ng/l; p<0.001) compare
to health subjects. There were strong association between serum BNP level
values in LC pts and values of : left atrial (LA) diameter (p=0.031), left
ventricular ejection fraction (LVEF) (p=0.014), pulmonary artery systolic
pressure (PASP) (p=0.000) and the presence of tricuspid valve regurgitation
(TVR) of 2+ (p=0.000), affecting its change of 41.6%. Conclusion. The
obtained results suggests that LC pts had significant ECG and EC signs for
myocardial dysfunction and the increased BNP serum level. LA diameter,
LVEF, PASP and TVR are valuable EC predictors of CCM.
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