Title
Značaj nivoa vitamina D i polimorfizama gena povezanih sa njegovim delovanjem kod obolelih od multiple skleroze : doktorska disertacija
Creator
Savić, Dejan 1973-
Copyright date
2013
Object Links
Select license
Autorstvo-Bez prerade 3.0 Srbija (CC BY-ND 3.0)
License description
Dozvoljavate umnožavanje, distribuciju i javno saopštavanje dela, bez promena, preoblikovanja ili upotrebe dela u svom delu, ako se navede ime autora na način odredjen od strane autora ili davaoca licence. Ova licenca dozvoljava komercijalnu upotrebu dela. Osnovni opis Licence: http://creativecommons.org/licenses/by-nd/3.0/rs/deed.sr_LATN Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
Other responsibilities
mentor
Vojinović, Slobodan
član komisije
Zoran Perić
član komisije
Slobodan Vojinović
član komisije
Evica Dinčić
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za neurologiju
Title translated
THE IMPORTANCE OF VITAMIN D LEVELS AND GENE POLYMORPHISMS RELATED WITH ITS ACTING IN PATIENTS WITH MULTIPLE SCLEROSIS
Publisher
Niš : [D. Savić]
Format
PDF/A (73 listova)
description
Biografija: listovi 67-68.
Umnoženo za odbranu. Univerzitet u Nišu, Medicinski fakultet, 2013.
Bibliografija: listovi 55-64.
Sažetak ; Summary.
Abstract (en)
Multiple sclerosis is disease which affect 2,5 million people worldwide and is one of the most frequent nontraumatic disabling neurological disorder among young adults. Multiple sclerosis is complex disease and so demands interaction between genetic and envinronmental factors. Among the environmental factors vitamin D has specific importance.
The aims of this study were estimating the vitamin D levels in multiple sclerosis patients and comparing with healthy individuals to estimate their importance in disease originate. We determinate single nucleotide polymorphisms rs2282679 for the vitamin D binding protein gene and rs10741657 for mycrosomal enzyme CYP2R1 gene and single nucleotide polymorphysm FokI (rs2228570) for vitamin D receptor gene.
Our results showed vitamin D insuffitiention in both groups with significantly lower values in multiple sclerosis group. Polymorphism rs2282679 for the vitamin D binding protein gene gene showed significant connection with vitamin D levels in healthy pepole. Vitamin D levels correlated with the degree of disability in patients group and disease type (secondary progressive versus relapsing - remitting). No one polymorphysm showed increasing the risk fom multiple sclerosis.
Vitamin D insuffitiention in whole population could be the aim for preventive acting, by suplementation of this essential dietetic product, esspecially according to its connection with the degree of neurological dysability. Established association between sertain polymorphisms and vitamin D levels could be means in establishing the aiming group for prevetive treatment. These study results represents one more piece in understanding this complex and underestimated disease.
Authors Key words
Multipla skleroza
Subject
616
Subject
57
Type
Elektronska teza
Abstract (en)
Multiple sclerosis is disease which affect 2,5 million people worldwide and is one of the most frequent nontraumatic disabling neurological disorder among young adults. Multiple sclerosis is complex disease and so demands interaction between genetic and envinronmental factors. Among the environmental factors vitamin D has specific importance.
The aims of this study were estimating the vitamin D levels in multiple sclerosis patients and comparing with healthy individuals to estimate their importance in disease originate. We determinate single nucleotide polymorphisms rs2282679 for the vitamin D binding protein gene and rs10741657 for mycrosomal enzyme CYP2R1 gene and single nucleotide polymorphysm FokI (rs2228570) for vitamin D receptor gene.
Our results showed vitamin D insuffitiention in both groups with significantly lower values in multiple sclerosis group. Polymorphism rs2282679 for the vitamin D binding protein gene gene showed significant connection with vitamin D levels in healthy pepole. Vitamin D levels correlated with the degree of disability in patients group and disease type (secondary progressive versus relapsing - remitting). No one polymorphysm showed increasing the risk fom multiple sclerosis.
Vitamin D insuffitiention in whole population could be the aim for preventive acting, by suplementation of this essential dietetic product, esspecially according to its connection with the degree of neurological dysability. Established association between sertain polymorphisms and vitamin D levels could be means in establishing the aiming group for prevetive treatment. These study results represents one more piece in understanding this complex and underestimated disease.
“Data exchange” service offers individual users metadata transfer in several different formats. Citation formats are offered for transfers in texts as for the transfer into internet pages. Citation formats include permanent links that guarantee access to cited sources. For use are commonly structured metadata schemes : Dublin Core xml and ETUB-MS xml, local adaptation of international ETD-MS scheme intended for use in academic documents.