Title
Analiza i upoređenje kvaliteta života bolesnika sa nemetastatskim karcinomom prostate koji su lečeni radikalnom prostatektomijom i hormonoterapijom
Creator
Dinić, Ljubomir, 1972-
CONOR:
75688201
Copyright date
2022
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 12.01.2023
Other responsibilities
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za radiologiju, nuklearnu medicinu i osnovi kliničke onkologije
Alternative title
Analysis and comparison of the quality of life in non-metastatic prostate cancer patients treated with radical prostatectomy and hormonal therapy
Publisher
[LJ. A. Dinić]
Format
[13], 178 listova
description
Biografija autora: list. 178,
Bibliografija: list. 137-165
description
Urology
Abstract (en)
The aim of the study was to evaluate health-related quality of life in
patients with non-metastatic prostate cancer. The patients were divided in
two groups. The first group consisted of patients who underwent RRP, and
the second group consisted of those who were primarily treated with
hormonal therapy for 12 months and then underwent external radiation
therapy (H + Z). The (EPIC) questionnaire was used to evaluate healthrelated
quality of life (HRQoL), the (IIEF-SF) questionnaire was used to
assess erectile function, the (ICIQ-UI) questionnaire was used to assess
urinary incontinence, and IPSS questionnaire was used to assess lower
urinary tract symptoms. All patients filled out questionnaires before the
start of treatment, in the 3rd, 6th, 12th, 15th, 18th and 24th months of followup.
At 12-month follow-up compared to baseline, the greatest decrease in
mean IIEF score (p < 0.05), the greatest increase in mean ICIQ-UI score
(p < 0.01), the greatest decrease in the mean IPSS score (p < 0.001), and
the greatest decrease in IPSS QoL score (p < 0.001) was in RRP group. For
HRQoL, according to the EPIC results, urinary function, urinary
incontinence and sexual function significantly decreased compared to
baseline after 12 months (p < 0.05 for all) in RRP group, and hormonal
function, sexual function and sexual bother (p < 0.001 for all) in the (H +
Z) group. From 12th to 24th months in the RRP group, there were no
changes in the mean IIEF, ICIQ-UI, IPSS, IPSS QoL scores compared to
the 12th month, nor in the HRQoL results. In the H + Z group, a significant
decrease in the IIEF score, a decrease in sexual function and sexual bother,
and an increase in hormonal function were verified. From a HRQoL
perspective, both treatment modalities can offer satisfactory functional
outcomes. RRP has the greatest impact on urinary and sexual function,
hormonal therapy on sexual and hormonal function, and H + Z on sexual
function and sexual bother.
Authors Key words
karcinom prostate, radikalna prostatektomija, hormono terapija, kvalitet
života
Authors Key words
prostate cancer, radical prostatectomy, hormone therapy, quality of life
Classification
616.65-006.6-089.87:615.357]:616-056.2(043.3)
Subject
B 560
Type
Tekst
Abstract (en)
The aim of the study was to evaluate health-related quality of life in
patients with non-metastatic prostate cancer. The patients were divided in
two groups. The first group consisted of patients who underwent RRP, and
the second group consisted of those who were primarily treated with
hormonal therapy for 12 months and then underwent external radiation
therapy (H + Z). The (EPIC) questionnaire was used to evaluate healthrelated
quality of life (HRQoL), the (IIEF-SF) questionnaire was used to
assess erectile function, the (ICIQ-UI) questionnaire was used to assess
urinary incontinence, and IPSS questionnaire was used to assess lower
urinary tract symptoms. All patients filled out questionnaires before the
start of treatment, in the 3rd, 6th, 12th, 15th, 18th and 24th months of followup.
At 12-month follow-up compared to baseline, the greatest decrease in
mean IIEF score (p < 0.05), the greatest increase in mean ICIQ-UI score
(p < 0.01), the greatest decrease in the mean IPSS score (p < 0.001), and
the greatest decrease in IPSS QoL score (p < 0.001) was in RRP group. For
HRQoL, according to the EPIC results, urinary function, urinary
incontinence and sexual function significantly decreased compared to
baseline after 12 months (p < 0.05 for all) in RRP group, and hormonal
function, sexual function and sexual bother (p < 0.001 for all) in the (H +
Z) group. From 12th to 24th months in the RRP group, there were no
changes in the mean IIEF, ICIQ-UI, IPSS, IPSS QoL scores compared to
the 12th month, nor in the HRQoL results. In the H + Z group, a significant
decrease in the IIEF score, a decrease in sexual function and sexual bother,
and an increase in hormonal function were verified. From a HRQoL
perspective, both treatment modalities can offer satisfactory functional
outcomes. RRP has the greatest impact on urinary and sexual function,
hormonal therapy on sexual and hormonal function, and H + Z on sexual
function and sexual bother.
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