Title
Uticaj polimorfizma CYP2B6, GABRE i ACCB1 gena na farmakodinamiku propofola tokom opšte anestezije kod abdominalnih histerektomija
Creator
Ivanov, Emilija G., 1963-
CONOR:
75662601
Copyright date
2021
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 07.10.2021.
Other responsibilities
predsednik komisije
Janković, Radmilo
član komisije
Veličković Radovanović, Radmila
član komisije
Jevtović Stoimenov, Tatjana
član komisije
Simić, Dušica
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za farmakologiju sa toksikologijom
Alternative title
The effects of CYP2B6, GABRE and ABCB1 genes polymorphysm on the pharmacodynamics of propofol during general anaesthesia fr abdominal hysterectomy
Publisher
[Е. G. Ivanov]
Format
110 listova
description
Biografija: list 108,
Bibliografija: listovi 92-103.
description
Anesthesiology
Abstract (en)
The inter individual variability in response to a drug is quite common
and depends on clinical, environmental, social and genetic factors.
Propofol (2,6-diisopropylphenol) is the most common intravenous
anesthetic used in modern medicine. It is postulated that individual
differences in genetic factors [polymorphism of single nucleotide
polymorphisms (SNPs)] in the genes encoding metabolic enzymes,
molecular transporters and molecular binding sites of propofol can be
responsible for susceptibility to propofol effects. The aim of our study
was to investigate the influence of the cytochrome P450 2B6 isozyme
CYP2B6 (rs3745274), γ -aminobutyric acid type A (GABAA) receptor
γ1 subunit GABRA1 (rs2279020) and ATP-binding cassette sub-family
B member 1 ABCB1 (rs1045642) gene polymorphisms on propofol
therapeutic outcomes in the patients undergoing abdominal
hysterectomy. Ninety patients aged 29-74 years, with different
ethnicities were included in this study. The presence of polymorphisms
was analyzed using TaqMan SNP genotype analysis on Stratagene
MxPro 3005P real-time polymerase chain reaction (qPCR). The
distribution of all three genetic variants was within the Hardy-
Weinberg equilibrium. There was no significant difference (p>0.05) in
the allelic frequencies of polymorphic variants and genotype
distributions between adult and older patients and between patients of
different ethnicities. Our study did not detect a statistically significant
influence of the CYP2B6 (c.516G>A), GABRA1 (c.1059+15G>A) and
ABCB1 (c.3435T>C) variants on the variability of clinical parameters
(doses for induction in anesthesia, additional doses, induction time and
wake time after anesthesia and side effects of propofol). However, the
observed trend on the possible influence of the CYP2B6 (c.516G>A)
and GABRA1 (c.1059+15G>A) variants warrant an extension of these
studies on a larger number of patients.
Authors Key words
ABCB1 gen; CYP2B6 gen; GABRA1 gen; farmakogenetika;
propofol
Authors Key words
ABCB1 gene; CYP2B6 gene; GABRA1 gene; Pharmacogenetic;
Propofol
Classification
616-089.5:575]:618.39-089.888(043.3)
Subject
B 590 Anesthesiology, intensive care
Type
Tekst
Abstract (en)
The inter individual variability in response to a drug is quite common
and depends on clinical, environmental, social and genetic factors.
Propofol (2,6-diisopropylphenol) is the most common intravenous
anesthetic used in modern medicine. It is postulated that individual
differences in genetic factors [polymorphism of single nucleotide
polymorphisms (SNPs)] in the genes encoding metabolic enzymes,
molecular transporters and molecular binding sites of propofol can be
responsible for susceptibility to propofol effects. The aim of our study
was to investigate the influence of the cytochrome P450 2B6 isozyme
CYP2B6 (rs3745274), γ -aminobutyric acid type A (GABAA) receptor
γ1 subunit GABRA1 (rs2279020) and ATP-binding cassette sub-family
B member 1 ABCB1 (rs1045642) gene polymorphisms on propofol
therapeutic outcomes in the patients undergoing abdominal
hysterectomy. Ninety patients aged 29-74 years, with different
ethnicities were included in this study. The presence of polymorphisms
was analyzed using TaqMan SNP genotype analysis on Stratagene
MxPro 3005P real-time polymerase chain reaction (qPCR). The
distribution of all three genetic variants was within the Hardy-
Weinberg equilibrium. There was no significant difference (p>0.05) in
the allelic frequencies of polymorphic variants and genotype
distributions between adult and older patients and between patients of
different ethnicities. Our study did not detect a statistically significant
influence of the CYP2B6 (c.516G>A), GABRA1 (c.1059+15G>A) and
ABCB1 (c.3435T>C) variants on the variability of clinical parameters
(doses for induction in anesthesia, additional doses, induction time and
wake time after anesthesia and side effects of propofol). However, the
observed trend on the possible influence of the CYP2B6 (c.516G>A)
and GABRA1 (c.1059+15G>A) variants warrant an extension of these
studies on a larger number of patients.
“Data exchange” service offers individual users metadata transfer in several different formats. Citation formats are offered for transfers in texts as for the transfer into internet pages. Citation formats include permanent links that guarantee access to cited sources. For use are commonly structured metadata schemes : Dublin Core xml and ETUB-MS xml, local adaptation of international ETD-MS scheme intended for use in academic documents.
