Title
Prognostički značaj inflamatornih medijatora iz pupčane vrpce i periferne krvi za razvoj sepse kod prevremeno rođene dece
Creator
Vučić, Jelena D. 1970-
Copyright date
2021
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 17.03.2021.
Other responsibilities
mentor
Stanković, Tatjana 1971-
predsednik komisije
Đurić, Zlatko
član komisije
Stamenković, Hristina
član komisije
Pavlović, Voja
član komisije
Ješić, Miloš
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za pedijatriju
Alternative title
ǂThe ǂimportance of inflamatory mediators from the umbilical cord and peripheral blood in the prediction of sepsis in preterm neonates
Publisher
[J. D. Vučić]
Format
[7], 86 listova
description
Biografija autora: list 83;
Bibliografija: listovi 67-82.
description
Pediatrics
Abstract (en)
Neonatal sepsis represents huge health problem worldwide with high level of morbidity. Preterm neonates are especially vulnerable group, due to immature immune system. Early detection of preterm sepsis is one of the main goal for better treatment of preterm neonates. Even there are numerious studies about the possible biomarkers for early detection of sepsis in preterm neonates, positive biomarkers for sepsis prediction still remain uncertain. In our study, we tried to evaluate some preterm clinical variables, as well as levels of certain cytokines and chemokines as potential biomarkers for sepsis prediction in preterm neonates. Results obtained in our study show that some clinical variables, IL-5 levels and some inflammatory markers (CRP and white cell count) do not have predictive value for sepsis development. Levels of procalcitonin and IFNγ, in venous blood, showed positive predictive potential for sepsis prediction in pretern neonates, 32.-36. gestational age. Values of analyzed chemokines (IL-8, MCP-1 i MIP-1α) corresponded with early sepsis development in cord blood but not in the venous blood. Evaluation of obtained results indicates that procalcitonin and IFNγ in venous blood and chemokine levels (IL-8, MCP-1 i MIP-1α) in cord blood may represet biomarkers with great potential for sepsis prediction in preterm neonates 32.-36. gestational age.
Authors Key words
prematurusi, septično stanje, krv pupčane vrpce, periferna krv, citokini, hemokini, predikcija
Authors Key words
preterm neonates, sepsis, cord blood, venous blood, cytokines, chemokines, prediction
Classification
618.38:[616.94-053.32(043.3)
Subject
B 660
Type
Tekst
Abstract (en)
Neonatal sepsis represents huge health problem worldwide with high level of morbidity. Preterm neonates are especially vulnerable group, due to immature immune system. Early detection of preterm sepsis is one of the main goal for better treatment of preterm neonates. Even there are numerious studies about the possible biomarkers for early detection of sepsis in preterm neonates, positive biomarkers for sepsis prediction still remain uncertain. In our study, we tried to evaluate some preterm clinical variables, as well as levels of certain cytokines and chemokines as potential biomarkers for sepsis prediction in preterm neonates. Results obtained in our study show that some clinical variables, IL-5 levels and some inflammatory markers (CRP and white cell count) do not have predictive value for sepsis development. Levels of procalcitonin and IFNγ, in venous blood, showed positive predictive potential for sepsis prediction in pretern neonates, 32.-36. gestational age. Values of analyzed chemokines (IL-8, MCP-1 i MIP-1α) corresponded with early sepsis development in cord blood but not in the venous blood. Evaluation of obtained results indicates that procalcitonin and IFNγ in venous blood and chemokine levels (IL-8, MCP-1 i MIP-1α) in cord blood may represet biomarkers with great potential for sepsis prediction in preterm neonates 32.-36. gestational age.
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