Title
Uticaj aterosklerotskih promena i faktora rizika na kognitivni status pacijenata sa asimptomatskom stenozom karotidnih arterija
Creator
Simeonovska Joveva, Elena S. 1979-
Copyright date
2020
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 05.03.2021.
Other responsibilities
mentor
Đorđević, Gordana 1965-
predsednik komisije
Vojinović, Slobodan
član komisije
Tončev, Gordana
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za internu medicinu
Alternative title
The influence of atherosclerotic changes and risk factors on the cognitive status of patients with asymptomatic carotid artery stenosis
Publisher
[Е. S. Simeonovska Јoveva]
Format
158 listova
description
Biografija autora: list 158;
Bibliografija: listovi 132-157.
description
Medicine, Neurology
Abstract (en)
The presence of carotid atherosclerosis is a potential risk factor for
disorder of cognitive functions. This was demonstrated by studies that
examined the relationship between carotid atherosclerosis and
cognitive disorder. Carotid artery stenosis and thickening of the
intima-media tissue (IMT) reflect different degrees of severity of the
atherosclerotic process. Carotid artery stenosis is defined as
atherosclerotic narrowing of the proximal part of the internal carotid
artery, 70% in severe cases and 50% in moderately severe cases. The
presence of lacunar infarcts of the brain is associated with an
increased risk of dementia. Vascular risk factors and inflammatory
mechanisms are involved in the atherosclerotic process, so
determining the inflammatory activation can also be useful in the risk
assessment in patients with carotid artery disease. In our study, the
following results were obtained with respect to the correlation of risk
factors, carotid stenosis and cognitive disorder. The study is
prospective, by analyzing a total of 180 patients divided into 3
groups, aged 50-70 years: 1. Patients with stenotic changes of varying
degrees but without symptoms (no transient ischemic attack or brain
infarction). 2. A group of patients with symptomatic stenotic changes
(transient ischemic attack or brain infarction). 3. Control group of
patients with headache and vertiginous disorders with normal carotid
artery finding. The presence of hypertension, diabetes,
hypercholesterolaemia, and circulating levels of inflammatory
markers (Tumor necrotic factor alpha, C reactive protein, fibrinogen
and sedimentation leucocyte formula) was evaluated. Ultrasound
examination was used as a method to determine the carotid
arteriosclerosis. Cognitive functions will be assessed using the
Addenbrooke’s cognitive examination (ACE-R) test. Computed
tomography of the brain was performed on receipt and after a period
of 24-72 hours of admission, the size and location of the acute
ischemic lesion would be analyzed. Nuclear magnetic resonance of
the brain was made over a period of 6 months in all patients.
Asymptomatic carotid stenosis increases the risk of cognitive
impairment, and the severe degree of carotid stenosis right increases
the risk of severe cognitive impairment about 14 times, and severe
carotid stenosis left increases the risk of severe cognitive impairment
about 20 times.
Authors Key words
ateroskleroza, karotidna stenoza, kognitivno oštećenje,
faktori vaskularnog rizika, inflamatorni markeri
Authors Key words
atherosclerosis, carotid stenosis, cognitive impairment, vascular risk
factors, inflammatory markers
Classification
616.133-007.271.-004.6(043.3)
Subject
B 640
Type
Tekst
Abstract (en)
The presence of carotid atherosclerosis is a potential risk factor for
disorder of cognitive functions. This was demonstrated by studies that
examined the relationship between carotid atherosclerosis and
cognitive disorder. Carotid artery stenosis and thickening of the
intima-media tissue (IMT) reflect different degrees of severity of the
atherosclerotic process. Carotid artery stenosis is defined as
atherosclerotic narrowing of the proximal part of the internal carotid
artery, 70% in severe cases and 50% in moderately severe cases. The
presence of lacunar infarcts of the brain is associated with an
increased risk of dementia. Vascular risk factors and inflammatory
mechanisms are involved in the atherosclerotic process, so
determining the inflammatory activation can also be useful in the risk
assessment in patients with carotid artery disease. In our study, the
following results were obtained with respect to the correlation of risk
factors, carotid stenosis and cognitive disorder. The study is
prospective, by analyzing a total of 180 patients divided into 3
groups, aged 50-70 years: 1. Patients with stenotic changes of varying
degrees but without symptoms (no transient ischemic attack or brain
infarction). 2. A group of patients with symptomatic stenotic changes
(transient ischemic attack or brain infarction). 3. Control group of
patients with headache and vertiginous disorders with normal carotid
artery finding. The presence of hypertension, diabetes,
hypercholesterolaemia, and circulating levels of inflammatory
markers (Tumor necrotic factor alpha, C reactive protein, fibrinogen
and sedimentation leucocyte formula) was evaluated. Ultrasound
examination was used as a method to determine the carotid
arteriosclerosis. Cognitive functions will be assessed using the
Addenbrooke’s cognitive examination (ACE-R) test. Computed
tomography of the brain was performed on receipt and after a period
of 24-72 hours of admission, the size and location of the acute
ischemic lesion would be analyzed. Nuclear magnetic resonance of
the brain was made over a period of 6 months in all patients.
Asymptomatic carotid stenosis increases the risk of cognitive
impairment, and the severe degree of carotid stenosis right increases
the risk of severe cognitive impairment about 14 times, and severe
carotid stenosis left increases the risk of severe cognitive impairment
about 20 times.
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