Title
Uloga nekontrastne magnetno-rezonantne perfuzije u dijagnostici, terapiji i prognozi kliničkog ishoda akutnog ishemijskog moždanog udara
Creator
Aracki-Trenkić, Aleksandra 1984-
Copyright date
2020
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 29.10.2020.
Other responsibilities
mentor
Stojanov, Dragan 1962-
predsednik komisije
Radovanović, Zoran
član komisije
Vojinović, Slobodan
član komisije
Kozić, Duško
član komisije
Petrović, Slađana
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za radiologiju, nuklearnu medicinu i osnovi kliničke onkologije
Alternative title
The role of non-contrast magnetic resonance perfusion in diagnostics, therapy and clinical outcome prognosis of acute ischemic stroke
Publisher
[A. Z. Aracki-Trenkić]
Format
162 lista
description
Biografija autora: list 162;
Bibliografija: listovi 131-161.
description
Radiology/Neuroradiology
Abstract (en)
Acute ischemic stroke (AIS) is an emergency condition causing the interruption of blood flow through one or more cerebral blood vessels. The discovery and application of advanced magnetic-resonance (MRI) techniques in clinical practice has significantly improved diagnostic accuracy in early detection of AIS, whereas the introduction of noncontrast arterial spin labeling (ASL) perfusion sequence is a significant milestone in neuroradiology.
This research aimed to demonstrate MRI as the method of choice in early diagnostics of AIS that provides insight into diagnostic and prognostic parameters. We examined the influence of a specific ASL sequence findings on the AIS functional outcome, in correlation with other protocol sequences findings.
The research was conducted as a prospective cross-sectional study at the Department of Radiology, Clinical Center Nis and the Department of Neuroradiology, University Hospital Pitié‐Salpêtrière, Paris.
The study included 205 patients of both sexes (aged ≥18 years) fulfilling clinical criteria for the diagnosis of AIS of the anterior cerebral circulation. All patients were examined on GE MRI scanners (field strength of 3T), using an ischemia protocol.
Results showed high efficiency of MRI in the detection of early hyperacute and acute ischemic lesions. The ASL perfusion sequence allows the detection of favorable AIS outcome predictors, primarily higher absolute cerebral blood flow (aCBF) values, the presence of arterial transient artifacts, and luxury perfusion. Significant certainty
Aleksandra Z. Aracki-Trenkić DOKTORSKA DISERTACIJA 7
in the detection of the occlusion site is achieved through the correlation of ASL and susceptibility weighted angiography (SWAN) sequence findings with the possibility of assessing the etiological type of AIS. A multivariate logistic regression analysis found the most significant predictors of favorable functional outcome were the involvement of the territory on the diffusion sequence and aCBF values.
In addition to early diagnosis of AIS, MRI with modern advanced sequences enables functional outcome prediction, thus influencing the choice of adequate therapy.
Authors Key words
Magnetno-rezonantni imidţing, akutni ishemijski moţdani udar, arterijsko obeleţavanje spinova, funkcionalni ishod
Authors Key words
Magnetic resonance imaging, acute ischemic stroke, arterial spin labeling, functional outcome
Classification
616.831-005.1-073:537.635(043.3)
Subject
B 725
Type
Tekst
Abstract (en)
Acute ischemic stroke (AIS) is an emergency condition causing the interruption of blood flow through one or more cerebral blood vessels. The discovery and application of advanced magnetic-resonance (MRI) techniques in clinical practice has significantly improved diagnostic accuracy in early detection of AIS, whereas the introduction of noncontrast arterial spin labeling (ASL) perfusion sequence is a significant milestone in neuroradiology.
This research aimed to demonstrate MRI as the method of choice in early diagnostics of AIS that provides insight into diagnostic and prognostic parameters. We examined the influence of a specific ASL sequence findings on the AIS functional outcome, in correlation with other protocol sequences findings.
The research was conducted as a prospective cross-sectional study at the Department of Radiology, Clinical Center Nis and the Department of Neuroradiology, University Hospital Pitié‐Salpêtrière, Paris.
The study included 205 patients of both sexes (aged ≥18 years) fulfilling clinical criteria for the diagnosis of AIS of the anterior cerebral circulation. All patients were examined on GE MRI scanners (field strength of 3T), using an ischemia protocol.
Results showed high efficiency of MRI in the detection of early hyperacute and acute ischemic lesions. The ASL perfusion sequence allows the detection of favorable AIS outcome predictors, primarily higher absolute cerebral blood flow (aCBF) values, the presence of arterial transient artifacts, and luxury perfusion. Significant certainty
Aleksandra Z. Aracki-Trenkić DOKTORSKA DISERTACIJA 7
in the detection of the occlusion site is achieved through the correlation of ASL and susceptibility weighted angiography (SWAN) sequence findings with the possibility of assessing the etiological type of AIS. A multivariate logistic regression analysis found the most significant predictors of favorable functional outcome were the involvement of the territory on the diffusion sequence and aCBF values.
In addition to early diagnosis of AIS, MRI with modern advanced sequences enables functional outcome prediction, thus influencing the choice of adequate therapy.
“Data exchange” service offers individual users metadata transfer in several different formats. Citation formats are offered for transfers in texts as for the transfer into internet pages. Citation formats include permanent links that guarantee access to cited sources. For use are commonly structured metadata schemes : Dublin Core xml and ETUB-MS xml, local adaptation of international ETD-MS scheme intended for use in academic documents.