Title
Komparativna klinička, imunološka, citogenetska i kariometrijska analiza akutnih leukemija : doktorska disertacija
Creator
Govedarović, Nenad, 1965-
Copyright date
2011
Object Links
Select license
Autorstvo-Bez prerade 3.0 Srbija (CC BY-ND 3.0)
License description
Dozvoljavate umnožavanje, distribuciju i javno saopštavanje dela, bez promena, preoblikovanja ili upotrebe dela u svom delu, ako se navede ime autora na način odredjen od strane autora ili davaoca licence. Ova licenca dozvoljava komercijalnu upotrebu dela. Osnovni opis Licence: http://creativecommons.org/licenses/by-nd/3.0/rs/deed.sr_LATN Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
Other responsibilities
mentor
Mihailović, Dragan
član komisije
Mačukanović, Lana
član komisije
Popović, Stevan, 1955-
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za internu medicinu
Title translated
Comparative clinic, immunologic, cytogenetic and karyometric analysis of acute leukemias
Publisher
Niš : [N. Govedarović]
Format
PDF/A (117 listova)
description
Biografija i bibliografija autora: str. 113-115.
Umnoženo za odbranu.
Univerzitet u Nišu, Medicinski fakultet., 2011, dr medicinskih nauka, hematologija.
Sažetak ; Summary.
Bibliografija: listovi 102-112.
Abstract (en)
Acute myeloid leukemia (AML) is a malignant disease with fulminant course, which results in a high percentage of patients remaining unfavourable.
The aim of our researche is to define potentially new prognostic factors and to campare them with standard, well established, prognostic factors in AML.
Study group included 123 newly diagnosed patients, with mean age about 65yr., with diagnosis AML Mo-M5, according to FAB classification.
After diagnosis, all patients underwent karyometricanalyses (eg. measure of leukemic blast nuclei parameters), convenctional karyotype analysis, molecular analyses of FLT3 ITD mutation, as well as immunofenotype analisis by flow cytometry.
According to results, it can be concluded that the main adverse actors in AML are: advanced age of patient, leucopenia or white blood cells count higher than 100000 x 10 on 9th/1 presence of FLT3 ITD mutation and higher siye of myeloblast's nuclei.
Authors Key words
Akutna mijeloidna leukemija, Citodijagnostika
Authors Key words
Subject
616
Type
Elektronska teza
Abstract (en)
Acute myeloid leukemia (AML) is a malignant disease with fulminant course, which results in a high percentage of patients remaining unfavourable.
The aim of our researche is to define potentially new prognostic factors and to campare them with standard, well established, prognostic factors in AML.
Study group included 123 newly diagnosed patients, with mean age about 65yr., with diagnosis AML Mo-M5, according to FAB classification.
After diagnosis, all patients underwent karyometricanalyses (eg. measure of leukemic blast nuclei parameters), convenctional karyotype analysis, molecular analyses of FLT3 ITD mutation, as well as immunofenotype analisis by flow cytometry.
According to results, it can be concluded that the main adverse actors in AML are: advanced age of patient, leucopenia or white blood cells count higher than 100000 x 10 on 9th/1 presence of FLT3 ITD mutation and higher siye of myeloblast's nuclei.
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