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Stanković, Milica, 1986-, 37389415
Primena koncepta dizajna kvaliteta u razvoju lipofilnog krema sa biljnim ekstraktima i masnim uljima
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Academic metadata
Doktorska disertacija
Medicinske nauke
Univerzitet u Nišu
Medicinski fakultet
Katedra za farmaciju
Other Theses Metadata
The application of quality by design concept in the development of lipophilic cream with plant extracts and fatty oils
[М. I. Stanković]
181 listova
Beleška o autoru: list 181;
Bibliografija: listovi 160-180.
Datum odbrane: 08.06.2020.
Pharmaceutical Technology
Nešić, Ivana 1965- (mentor)
Ibrić, Svetlana (predsednik komisije)
Sunarić, Slavica (član komisije)
Živković, Jelena (član komisije)
Tadić, Vanja (član komisije)
The aim of the PhD thesis was pharmaceutical development of
lipophilic cream with active components of plant origin, which
contains optimal combination of standardized fruit extract and fatty
oil of blackthorn, dog rose, elderberry and rowanberry (Prunus
spinosa L., Rosa canina L., Sambucus nigra L. and Sorbus aucuparia
L., respectively), with satisfactory stability, safety, efficiency and
applicative properties, using quality bу design concept. In vitro
examination of ultrasonic fruit extracts with different solvents
(methanol, 70% ethanol, 45% propylene glycol, purified water)
included physico-chemical properties determination, polyphenolic
compounds, organic acids and vitamins contents analyses, evaluation
of antioxidant and anti-tyrosinase activity and influence on fibroblasts
viability. As the richest source of bioactive compounds, with good
antioxidative and anti-tyrosinase activity and positive influence on
fibroblasts viability, an aqueous extract of rose hip at concentration of
3.5% was selected for incorporation into lipophilic cream. After the
yields of fruit fatty oils obtained by Soxhlet and supercritical
extraction were compared, a better efficiency of the supercritical
extraction method for fatty oil isolation from seeds was found.
Analysis of fatty acid content in the fruit and seed oils was carried out
by gas chromatography. Blackthorn, rose hip and elderberry seed oils
were selected for cream formulation at concentrations corresponding
to the linoleic acid content of 0.815%. Organoleptic evaluation of
lipophilic creams, physicochemical stability testing (pH value,
electrical conductivity, centrifugation test) during the 12 months
study, sensory characteristics analysis and in vivo estimation of
irritation potential (as an aspect of skin application safety) and
efficiency (effects on hydration, surface lipid content, skin pH,
melanin index, as well as transepidermal water loss), showed that
lipophilic cream with rose hip extract (35 mg/g) and blackthorn seed
oil (22.4 mg/g) had optimal sensory characteristics, stability,
favorable safety profile and the highest application efficiency, so it is
suggested as potential pharmaceutical preparation for the treatment of
dry skin, changes associated with atopic dermatitis (pruritis, xerosis,
eczema), hyperpigmentations, UV radiation protection and oxidative
stress, which lead to the loss of skin vitality and photoaging.
quality by design; lipophilic cream; blackthorn, dog rose, elderberry
and rowanberry fruit extracts; fatty oils; supercritical extraction;
linoleic acid; dry skin; atopic dermatitis; oxidative stress
665.584.2:615.322.012(043.3)
B 740
Serbian
17651721
Tekst
The aim of the PhD thesis was pharmaceutical development of
lipophilic cream with active components of plant origin, which
contains optimal combination of standardized fruit extract and fatty
oil of blackthorn, dog rose, elderberry and rowanberry (Prunus
spinosa L., Rosa canina L., Sambucus nigra L. and Sorbus aucuparia
L., respectively), with satisfactory stability, safety, efficiency and
applicative properties, using quality bу design concept. In vitro
examination of ultrasonic fruit extracts with different solvents
(methanol, 70% ethanol, 45% propylene glycol, purified water)
included physico-chemical properties determination, polyphenolic
compounds, organic acids and vitamins contents analyses, evaluation
of antioxidant and anti-tyrosinase activity and influence on fibroblasts
viability. As the richest source of bioactive compounds, with good
antioxidative and anti-tyrosinase activity and positive influence on
fibroblasts viability, an aqueous extract of rose hip at concentration of
3.5% was selected for incorporation into lipophilic cream. After the
yields of fruit fatty oils obtained by Soxhlet and supercritical
extraction were compared, a better efficiency of the supercritical
extraction method for fatty oil isolation from seeds was found.
Analysis of fatty acid content in the fruit and seed oils was carried out
by gas chromatography. Blackthorn, rose hip and elderberry seed oils
were selected for cream formulation at concentrations corresponding
to the linoleic acid content of 0.815%. Organoleptic evaluation of
lipophilic creams, physicochemical stability testing (pH value,
electrical conductivity, centrifugation test) during the 12 months
study, sensory characteristics analysis and in vivo estimation of
irritation potential (as an aspect of skin application safety) and
efficiency (effects on hydration, surface lipid content, skin pH,
melanin index, as well as transepidermal water loss), showed that
lipophilic cream with rose hip extract (35 mg/g) and blackthorn seed
oil (22.4 mg/g) had optimal sensory characteristics, stability,
favorable safety profile and the highest application efficiency, so it is
suggested as potential pharmaceutical preparation for the treatment of
dry skin, changes associated with atopic dermatitis (pruritis, xerosis,
eczema), hyperpigmentations, UV radiation protection and oxidative
stress, which lead to the loss of skin vitality and photoaging.
https://phaidrani.ni.ac.rs/detail_object/o:1667?tab=0#mda
