Title
Uticaj genskih polimorfizama enzima uključenih u metabolizam ksenobiotika na patogenezu i klinički tok hronične opstruktivne bolesti pluća
Creator
Milačić, Nena N.
Copyright date
2019
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 10.12.2019.
Other responsibilities
mentor
Milojković, Maja
predsednik komisije
Bojanić, Vladmila
član komisije
Stanković, Ivana
član komisije
Jevtović Stoimenov, Tatjana
član komisije
Mihaljević, Olgica
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za internu medicinu
Alternative title
The influence of xenobiotic metabolizing enzymes' genetic polymorphisms on pathogenesis and clinical evolution of chronic obstructive pulmonary disease
Publisher
[N. N. Milačić]
Format
103 lista
description
Biografija autora: list [106];
Bibliografija: listovi 81-103.
description
Pathological physiology, Pulmonology
Abstract (en)
The results obtained show that the frequency of the heterozygous MDR1
C3435T is significantly higher in COPD patients in comparison to the control
group (p <0.004). T allele MDR1 3435 was more common in smokers compared
to non-smokers (p = 0.035). Within the clinical group, the number of leukocytes
and sedimentation were in statistically significant correlation with the presence
of altered T-allele of gene polymorphism MDR1 3435 (p = 0.012).
The incidence of CYP3A5*1*3 (heterozygous form and homozygous form) was
significantly higher in patients with COPD compared to those of the respondents
(43.3% vs. 11.6%, p <0.001). The co-morbidity of COPD patients was
statistically significantly more common in patients with non-functional CYP3A5
(p = 0.025). The pH values were statistically significantly higher in patients with
functional form CYP3A5 (p = 0.046).
The distribution of the genotype GG, GA and AA-308 TNF-α did not differ
statistically in the group of patients with COPD compared to the control group
of healthy subjects (p = 0.268). The number of neutrophils was statistically
significantly higher in patients with COPD GG-308 TNF-α compared to A-allele
carriers of this gene polymorphism (GA and AA-308 TNF-α) (p = 0.067). The
pH value was significantly higher in patients with GG-308 TNF-α genotype
carriers compared to carrier A-alleles of this gene polymorphism (GA and AA-
308 TNF-α) (p = 0.016). The GG-308 genotype TNF-α is the most common in
COPD patients with BMI≤18.5 and in the BMI group of 18-24.9.
Based on the obtained results, it can be concluded that the variant forms of
genes encoding enzymes involved in the xenobiotic metabolism - MDR1
C3435T and CYP3A5*3 are significantly more frequently present in patients
with COPD compared to the control group of healthy subjects. In addition, the
number of leukocytes and sedimentation are in correlation with the changed
genetic status of MDR1 C3435T, and comorbidities are significantly more
common in patients with non-functional CYP3A5*3. Genetic status of GA-308
TNF-α was statistically significantly related to the number of neutrophils,
whereas the presence of T-allele-308 TNF-α was not more common in patients
with COPD compared to healthy subjects.
Authors Key words
HOBP, polimorfizmi jednog nukleotida, MDR1, TNF-α, CYP3A5
Authors Key words
COPD, single nucleotide polymorphisms, MDR1, TNF-α, CYP3A5
Classification
616.24-008.4-092:[575.113:615.23(043.3)
Subject
B540
Type
Tekst
Abstract (en)
The results obtained show that the frequency of the heterozygous MDR1
C3435T is significantly higher in COPD patients in comparison to the control
group (p <0.004). T allele MDR1 3435 was more common in smokers compared
to non-smokers (p = 0.035). Within the clinical group, the number of leukocytes
and sedimentation were in statistically significant correlation with the presence
of altered T-allele of gene polymorphism MDR1 3435 (p = 0.012).
The incidence of CYP3A5*1*3 (heterozygous form and homozygous form) was
significantly higher in patients with COPD compared to those of the respondents
(43.3% vs. 11.6%, p <0.001). The co-morbidity of COPD patients was
statistically significantly more common in patients with non-functional CYP3A5
(p = 0.025). The pH values were statistically significantly higher in patients with
functional form CYP3A5 (p = 0.046).
The distribution of the genotype GG, GA and AA-308 TNF-α did not differ
statistically in the group of patients with COPD compared to the control group
of healthy subjects (p = 0.268). The number of neutrophils was statistically
significantly higher in patients with COPD GG-308 TNF-α compared to A-allele
carriers of this gene polymorphism (GA and AA-308 TNF-α) (p = 0.067). The
pH value was significantly higher in patients with GG-308 TNF-α genotype
carriers compared to carrier A-alleles of this gene polymorphism (GA and AA-
308 TNF-α) (p = 0.016). The GG-308 genotype TNF-α is the most common in
COPD patients with BMI≤18.5 and in the BMI group of 18-24.9.
Based on the obtained results, it can be concluded that the variant forms of
genes encoding enzymes involved in the xenobiotic metabolism - MDR1
C3435T and CYP3A5*3 are significantly more frequently present in patients
with COPD compared to the control group of healthy subjects. In addition, the
number of leukocytes and sedimentation are in correlation with the changed
genetic status of MDR1 C3435T, and comorbidities are significantly more
common in patients with non-functional CYP3A5*3. Genetic status of GA-308
TNF-α was statistically significantly related to the number of neutrophils,
whereas the presence of T-allele-308 TNF-α was not more common in patients
with COPD compared to healthy subjects.
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