Title
Prognostički značaj nuklearne morfometrije i imunohistohemijskih parametara kod melanoma kože
Creator
Veličkov, Asen V., 1983-
Copyright date
2018
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 13.11.2018.
Other responsibilities
mentor
Kovačević, Predrag 1969-
član komisije
Tiodorović, Danica
član komisije
Pejčić, Ivica 1957-
član komisije
Kozarski, Jefta
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za hirurgiju
Alternative title
Pronostic significance of nuclear morphometry and immunohistochemical parameters in skin melanoma
Publisher
[A. V. Veličkov]
Format
184 listova
description
Beleška o autoru: list 181;
Bibliografija: listovi 139-178.
description
Surgery, pathology
Abstract (en)
The goal was to prove the prognostic significance of nuclear-morphometric and immunohistochemical parameters in skin melanoma.
Methodology: Epidemiological parameters (sex, age and localization) and biological properties (recidives, metastases) were analyzed (timespan from 2002 to 2016). Nuclear-morphometric and immunohistochemical parameters were also analyzed. Statistical data processing provided the connection between the evaluated parameters and their prognostic value.
Significance of the research: The existence of a link between the biological course of skin melanoma and nuclear-morphometric and immunohistochemical parameters has been established. The increase in total intratumoral concentrations of CD4 and CD8 positive cells, as well as the increased proportion of these cells compared to the unstained cells of the same morphological characteristics, led to a good prognosis. The intensity of CD4 staining was also positively correlated with good prognosis. The increased count of CD15 positive cells along with the increase of Area, Circularity, IntDen, and Roundness predicts a good prognosis. The increase in Circularity and Roundness, as well as the increased concentration of peritumor CD15 cells, led to a worse prognosis. The lower CD117 level with increasing circularity and roundness may also indicate a poor prognosis of the disease. The CD8 parameters correlated with CD4 and CD15 parameters. Roundness showed a negative relation with the CD117 parameters. This represents the original scientific contribution of this dissertation.
Authors Key words
Melanom kože, nuklearna morfometrija, imunohistohemijski parametri, CD4, CD8, CD15, CD117
Authors Key words
Skin melanoma, nuclear morphometry, immunohistochemical parameters, CD4, CD8, CD15, CD117
Classification
616.5-006.81-036-076(043.3)
Subject
B 200; B 520; B 600; B 630
Type
Tekst
Abstract (en)
The goal was to prove the prognostic significance of nuclear-morphometric and immunohistochemical parameters in skin melanoma.
Methodology: Epidemiological parameters (sex, age and localization) and biological properties (recidives, metastases) were analyzed (timespan from 2002 to 2016). Nuclear-morphometric and immunohistochemical parameters were also analyzed. Statistical data processing provided the connection between the evaluated parameters and their prognostic value.
Significance of the research: The existence of a link between the biological course of skin melanoma and nuclear-morphometric and immunohistochemical parameters has been established. The increase in total intratumoral concentrations of CD4 and CD8 positive cells, as well as the increased proportion of these cells compared to the unstained cells of the same morphological characteristics, led to a good prognosis. The intensity of CD4 staining was also positively correlated with good prognosis. The increased count of CD15 positive cells along with the increase of Area, Circularity, IntDen, and Roundness predicts a good prognosis. The increase in Circularity and Roundness, as well as the increased concentration of peritumor CD15 cells, led to a worse prognosis. The lower CD117 level with increasing circularity and roundness may also indicate a poor prognosis of the disease. The CD8 parameters correlated with CD4 and CD15 parameters. Roundness showed a negative relation with the CD117 parameters. This represents the original scientific contribution of this dissertation.
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