Title
Histohemijska, imunohistohemijska i morfometrijska analiza promena na srčanom mišiću kod heroinskih zavisnika
Creator
Milić, Miroslav S. 1976-
Copyright date
2018
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 06.09.2018.
Other responsibilities
mentor
Ilić, Goran
predsednik komisije
Karadžić, Radovan
član komisije
Savić, Slobodan
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za sudsku medicinu
Alternative title
Histochemical, immunohistochemical and morphometric analysis of changes in heart muscle in heroin addicts
Publisher
[М. S. Milić]
Format
144 lista
description
Beleška o autoru: list 144;
Bibliografija: listovi 123-143.
description
Legal medicine
Abstract (en)
In order to clarify the mechanism of heroin addicts death, besides changes in the
lungs, which were most frequently studied, changes in the heart muscle were also
observed. The weakening of the contractility of the myocardium and the binding of
the connective tissue in the heart muscle are considered to be the basis for the
development of possible pathogenetic mechanisms of dying. In order to define
micro-morphological changes on the myocardium, histochemical,
immunohistochemical and morphometric analysis determines the qualitative
characteristics of cardiomyocytes and connective tissue, as well as the number of
inflammatory cells in the myocardium (leucocytes, monocytes and macrophages, Tlymphocytes
and mastocytes) of 42 cadavers whose death is in relation to the heroin
abuse, and 10 cadavers from the control group. The quantification of these
parameters was performed by measuring the thickness of the myocardiocyte and
determining the percentage of connective tissue representation, and counting
specific cell types in 30 visual fields in each of the 6 myocardial samples taken from
the defined sites. The mean values were analyzed statistically. The connective tissue
was statistically significantly present in the heroin addicts myocard in relation to the
control group (p = 0.001). Cardiomyocytes were statistically significantly thicker in
heroine addicts for p = 0.005. The number of leukocyte was significantly lower in
the left ventricle compared to the right ventricle and the intraventricular septum (p =
0.02) for heroin addicts. Statistically significant differences between the sexes and
between the groups defined by the length of heroin use were not recorded for the
analyzed parameters. Cardiomyocyte hypertrophy, presence of connective tissue,
and the presence of certain immune response cells indicate that prolonged use of the
herion over time can lead to dysfunction of the heart muscle and heartbeat system,
which may represent the cause of the death of heroin addicts.
Authors Key words
obdukcija, heroin, miokard, vezivno tkivo, morfometrija
Authors Key words
autopsy, heroin, myocardium, connective tissue, morphometry
Classification
616.127-091.5:616-056.83(043.3)
Subject
B770
Type
Tekst
Abstract (en)
In order to clarify the mechanism of heroin addicts death, besides changes in the
lungs, which were most frequently studied, changes in the heart muscle were also
observed. The weakening of the contractility of the myocardium and the binding of
the connective tissue in the heart muscle are considered to be the basis for the
development of possible pathogenetic mechanisms of dying. In order to define
micro-morphological changes on the myocardium, histochemical,
immunohistochemical and morphometric analysis determines the qualitative
characteristics of cardiomyocytes and connective tissue, as well as the number of
inflammatory cells in the myocardium (leucocytes, monocytes and macrophages, Tlymphocytes
and mastocytes) of 42 cadavers whose death is in relation to the heroin
abuse, and 10 cadavers from the control group. The quantification of these
parameters was performed by measuring the thickness of the myocardiocyte and
determining the percentage of connective tissue representation, and counting
specific cell types in 30 visual fields in each of the 6 myocardial samples taken from
the defined sites. The mean values were analyzed statistically. The connective tissue
was statistically significantly present in the heroin addicts myocard in relation to the
control group (p = 0.001). Cardiomyocytes were statistically significantly thicker in
heroine addicts for p = 0.005. The number of leukocyte was significantly lower in
the left ventricle compared to the right ventricle and the intraventricular septum (p =
0.02) for heroin addicts. Statistically significant differences between the sexes and
between the groups defined by the length of heroin use were not recorded for the
analyzed parameters. Cardiomyocyte hypertrophy, presence of connective tissue,
and the presence of certain immune response cells indicate that prolonged use of the
herion over time can lead to dysfunction of the heart muscle and heartbeat system,
which may represent the cause of the death of heroin addicts.
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