Title
Značaj inflamatornih markera i poremećaja sistema hemostaze kod bolesnika sa akutnim pankreatitisom
Creator
Tešić Rajković, Snežana K.
Copyright date
2017
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 22.05.2018.
Other responsibilities
mentor
Radovanović-Dinić, Biljana 1965-
predsednik komisije
Nagorni, Aleksandar
član komisije
Marjanović, Goran
član komisije
Jevtović Stimenov, Tatjana
član komisije
Đuranović, Srđan
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za internu medicinu
Alternative title
The significance of inflammatory markers and disorders of hemostasis in patients with acute pancreatitis
Publisher
[S. K. Tešić Rajković]
Format
146 listova
description
Bibliografija: listovi 113-146.
description
Gastroenterology and hepatology
Abstract (en)
A possibility to develop sever systemic complications of acute pancreatitis(AP) demands timely assessment of the severity of the disease in order to make an optimal therapeutic approach and a correct prognosis of the disease.
The aim of the study was to establish the role of certain individual inflammatory biomarkers and
coagulation parameters in the prediction of AP severity, and also to propose a mathematical formula which allows there combined use for the same purpose.
Methods.
The prospective study included 92 patients with AP. The patients were divided into groups: mild,
moderate and severe AP.
Results.
Based on the results of Mann-Whitney,s test, it can be concluded that a statistically significant
difference between groups A(mild) and B(moderate and severe) for CRP (p<0.05). Using the Wald’s stepwise forward method, a prediction model with CRP, PCT, D-dimer 1, D-dimer 3, fibrinogen 1 and fibrinogen 3 parameters as predictors of the severity of AP has been obtained. The percentage of successful prediction of moderate or severe AP based on this model is 76.9%.
Conclusion.
The combined analysis of biohumoral markers and coagulation parameters presented in the form a mathematical formula can enable a more accurate, rapid, rational and clinically available prediction of the severity of AP.
Authors Key words
Akutni pankreatitis, prokalcitonin, C reaktivni protein, D dimer
Authors Key words
acute pancreatitis, procalcitonin, C reactive protein, D dimer
Classification
611.1.37
Subject
616.37-002.1-005:577.1(043.3)
Subject
B 550
Type
Tekst
Abstract (en)
A possibility to develop sever systemic complications of acute pancreatitis(AP) demands timely assessment of the severity of the disease in order to make an optimal therapeutic approach and a correct prognosis of the disease.
The aim of the study was to establish the role of certain individual inflammatory biomarkers and
coagulation parameters in the prediction of AP severity, and also to propose a mathematical formula which allows there combined use for the same purpose.
Methods.
The prospective study included 92 patients with AP. The patients were divided into groups: mild,
moderate and severe AP.
Results.
Based on the results of Mann-Whitney,s test, it can be concluded that a statistically significant
difference between groups A(mild) and B(moderate and severe) for CRP (p<0.05). Using the Wald’s stepwise forward method, a prediction model with CRP, PCT, D-dimer 1, D-dimer 3, fibrinogen 1 and fibrinogen 3 parameters as predictors of the severity of AP has been obtained. The percentage of successful prediction of moderate or severe AP based on this model is 76.9%.
Conclusion.
The combined analysis of biohumoral markers and coagulation parameters presented in the form a mathematical formula can enable a more accurate, rapid, rational and clinically available prediction of the severity of AP.
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