Title
Intersticijalne ćelije kahala u gastrointestinalnom traktu pacova sa dijabetesom melitusom izazvanim streptozotocin-nikotinamidom
Creator
Veličkov, Aleksandra I. 1979-
Copyright date
2018
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 05.04.2018.
Other responsibilities
mentor
Radenković, Goran
predsednik komisije
Avramović, Verica
član komisije
Sokolović, Dušan
član komisije
Mihailović, Dragan
član komisije
Lalošević, Dušan
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za histologiju sa embriologijom
Alternative title
Interstitial cells of cajal in the gastrointestinal tract of rat with streptozotocin-nicotinamide induced diabetes mellitus
Publisher
[А. I. Veličkov]
Format
151 list
description
Beleška o autoru: list [152];
Bibliografija: listovi 135-151
description
histology and embryology, pathology
Abstract (en)
Interstitial cells of Cajal (ICC) are non-neural cells of mesenchymal
origin inserted between nerve elements and smooth muscle cells in the
gastrointestinal tract (GIT). ICC are necessary for normal function of
gastrointestinal (GI) tract and according to their morphology, function
and localization, ICC are classified in several subtypes. Certain ICC
subtypes serve as source of electrical slow waves which are
electrophysiological foundation of peristalsis, while other ICC
subtypes are mediators and modulators of enteric motor
neurotransmission, mechanoreceptors and are responsible for proper
function of GIT sphincters. Mechanism of diabetic gastroenteropathy
(DG) is unclear. ICC disorders caused by metabolic changes in
diabetes (DM) could explain symptoms of DG (gastroparesis, slow
intestinal transit, constipation, fecal incontinence). The aim of research
is to determine ICC distribution and morphology in GIТ of rats in
control group and rats with streptozotocin-nicotinamide induced DM
using immunohistochemical and morphometric methods. The results of
doctoral dissertation showed that all ICC subtypes are present in the
GIT of the rat, with regional distribution and density differences. In the
DM group, there was a significant diffuse loss of all subtypes of ICC
in GIT, while the density of nerve structures remained unchanged.
Authors Key words
Intersticijalne ćelije Kahala, dijabetes melitus,
gastrointestinalni trakt, streptozotocin, nikotinamid
Authors Key words
Interstitial cells of Cajal, diabetes mellitus, gastro intestinal tract,
streptozotocin, nicotinamide
Classification
611.018.1:616.379-008.64:616.33/34-008.1(043.3)
Subject
B440; B480; B 520; B 550
Type
Elektronska teza
Abstract (en)
Interstitial cells of Cajal (ICC) are non-neural cells of mesenchymal
origin inserted between nerve elements and smooth muscle cells in the
gastrointestinal tract (GIT). ICC are necessary for normal function of
gastrointestinal (GI) tract and according to their morphology, function
and localization, ICC are classified in several subtypes. Certain ICC
subtypes serve as source of electrical slow waves which are
electrophysiological foundation of peristalsis, while other ICC
subtypes are mediators and modulators of enteric motor
neurotransmission, mechanoreceptors and are responsible for proper
function of GIT sphincters. Mechanism of diabetic gastroenteropathy
(DG) is unclear. ICC disorders caused by metabolic changes in
diabetes (DM) could explain symptoms of DG (gastroparesis, slow
intestinal transit, constipation, fecal incontinence). The aim of research
is to determine ICC distribution and morphology in GIТ of rats in
control group and rats with streptozotocin-nicotinamide induced DM
using immunohistochemical and morphometric methods. The results of
doctoral dissertation showed that all ICC subtypes are present in the
GIT of the rat, with regional distribution and density differences. In the
DM group, there was a significant diffuse loss of all subtypes of ICC
in GIT, while the density of nerve structures remained unchanged.
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