Title
Uticaj ekstrakata lista zelenog čaja i ploda borovnice na tok akutne bubrežne insuficijencije pacova izazvane gentamicinom
Creator
Veljković, Milica S., 1984-
Copyright date
2017
Object Links
Select license
Autorstvo-Nekomercijalno-Deliti pod istim uslovima 3.0 Srbija (CC BY-NC-SA 3.0)
License description
Dozvoljavate umnožavanje, distribuciju i javno saopštavanje dela, i prerade, ako se navede ime autora na način odredjen od strane autora ili davaoca licence i ako se prerada distribuira pod istom ili sličnom licencom. Ova licenca ne dozvoljava komercijalnu upotrebu dela i prerada. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-sa/3.0/rs/deed.sr_LATN Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-sa/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 27.04.2017.
Other responsibilities
mentor
Radenković, Mirjana
predsednik komisije
Stojiljković, Nenad
član komisije
Rosić, Mirko
član komisije
Sokolović, Dušan
član komisije
Pavlović, Dragana
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za fiziologiju
Alternative title
Effects of green tea leaf and bilberry fruit extracts on gentamicin-induced acute renal failure.
Publisher
[M. Veljković]
Format
100 listova
description
Biografija autora: list 100
description
Physiology
Abstract (en)
We assessed effects of bilberry and green tea diet in rat model of gentamicininduced
nephrotoxicity by monitoring functional and morphological changes
in kidneys. The study was conducted on six groups of rats: control group (C),
treated with only gentamicin (GM), treated with only green tea (GT), treated
with only bilberry (B), treatedwith both gentamicin and green tea (GT+GM)
and treated with both gentamicin and bilberry (B+GM). Kidney function,
oxidant and antioxidant parameters of renal tissue, as well as
histopathological studies were assessed. Morphometric analysis was used to
quantify these histopathological changes. Gentamicin caused significant
elevations in serum creatinine and urea and oxidative stress parameters (MDA
and AOPP), while antioxidative enzyme catalase was significantly decreased.
Histological sections of kidneys in GM group revealed necrosis of proximal
tubules, vacuolation of cytoplasm and massive mononuclear inflammatory
infiltrates in interstitium. Coadministration of green tea and bilberry with
gentamicin histologically showed renoprotective effect. Histological results
were confirmed and quantified by morphometric analysis. Also in GT+GM
and B+GM group we measured ameliorated parameters of renal functions and
antioxidative defense. Regenerative potential of green tea and bilberry after
renal injury induced by gentamicin could be explained through the decrease of
oxidative stress and lipid peroxidation. Green tea and bilberry are both natural
antioxidants, and could be beneficial in the reduction of oxidative stress and
changes caused by it primarily in renal tubules and interstitium.
Authors Key words
gentamicin, zeleni čaj, borovnica, pacov, nefrotoksičnost, oksidativni stres,
antioksidans
Authors Key words
gentamicin, green tea, bilberry, rat, nephrotoxicity, oxidative stress,
antioxidant
Classification
612.466.08:615.322(043.2)
Subject
B 470
Type
Elektronska teza
Abstract (en)
We assessed effects of bilberry and green tea diet in rat model of gentamicininduced
nephrotoxicity by monitoring functional and morphological changes
in kidneys. The study was conducted on six groups of rats: control group (C),
treated with only gentamicin (GM), treated with only green tea (GT), treated
with only bilberry (B), treatedwith both gentamicin and green tea (GT+GM)
and treated with both gentamicin and bilberry (B+GM). Kidney function,
oxidant and antioxidant parameters of renal tissue, as well as
histopathological studies were assessed. Morphometric analysis was used to
quantify these histopathological changes. Gentamicin caused significant
elevations in serum creatinine and urea and oxidative stress parameters (MDA
and AOPP), while antioxidative enzyme catalase was significantly decreased.
Histological sections of kidneys in GM group revealed necrosis of proximal
tubules, vacuolation of cytoplasm and massive mononuclear inflammatory
infiltrates in interstitium. Coadministration of green tea and bilberry with
gentamicin histologically showed renoprotective effect. Histological results
were confirmed and quantified by morphometric analysis. Also in GT+GM
and B+GM group we measured ameliorated parameters of renal functions and
antioxidative defense. Regenerative potential of green tea and bilberry after
renal injury induced by gentamicin could be explained through the decrease of
oxidative stress and lipid peroxidation. Green tea and bilberry are both natural
antioxidants, and could be beneficial in the reduction of oxidative stress and
changes caused by it primarily in renal tubules and interstitium.
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