General Metadata
Title
Aktivnost antioksidativnih enzima eritrocita kod obolelih od hroničnog hepatitisa C, lečenih pegilovanim interferorom alfa-2A i ribavirinom
Creator
Popović Dragonjić, Lidija D. 1981-
Copyright date
2016
Object Links
Permanent link
Full text preview
Download link
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
1025568749
Academic metadata
Theses Type
Doktorska disertacija
description
Datum odbrane: 03.06.2016.
Other responsibilities
mentor
Jovanović, Maja
predsednik komisije
Kocić, Gordana
član komisije
Brkić, Snežana
član komisije
Cvetković, Tatjana
član komisije
Vrbić, Miodrag
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za infektologiju i epidemiologiju
Other Theses Metadata
Abstract (en)
Background: Antioxidant imbalance is major trigger for chronic hepatitis C (CHC) occurrence and progression. Aim: To determine the erythrocyte antioxidative enzymes activities, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT), before and after therapy with pegylated interferon alpha-2a and ribavirin and to evaluate their clinical significance as potential diagnostic markers of sustained virological response (SVR). Methods: SOD, GPx, CAT, liver function parameters and high sensitivity C reactive protein (hsCRP) levels were measured in 53 CHC patients both before and after treatment and in 56 healthy controls. Results: Baseline SOD, GPx and CAT activities were significantly lower in CHC patients compared to the controls (p<0.001), and they were significantly higher after the treatment (p<0.001). A significant positive correlation existed between SOD, GPx, CAT, before and after treatment (p<0.001) and with aminotransferases prior to treatment (p<0.001). After treatment, only GPx showed significant negative correlation with aminotransferases (p<0.001). Receiver operating characteristic curve analysis results for SOD, GPx and CAT are following: area under the curve of 0.975, 0.988, 0.817; sensitivity of 93.5%, 71.7%, 100% and specificity of 100% for all, respectively. 46 SVR achievers have significant increase of SOD, GPx and CAT activities (p<0.001 for all), unlike 7 SVR non-achievers (p=0.31, p=0.717, p =0.85 respectively). SOD, CAT, GPx levels are statistically higher (p<0.001 for all) in patients with: hepatitis C virus genotypes 1 and 4 compared to genotypes 2 and 3, higher levels of fibrosis compared to lower, SVR achievers compared to SVR non-achievers. HsCRP levels are significantly raised in CHC patients with decreased antioxidant enzymes activities (p<0.05). Conclusion: Antioxidant imbalance is the initiator of onset and progression of CHC. The combined antiviral therapy leads to the restoration of antioxidant balance. GPx, SOD and CAT may be diagnostic markers of treatment outcome.