Title
Procena uticaja leptina, grelina i tiroidne funkcije na tip ishranjenosti dece i adolescenata
Creator
Miljković, Mirjana N. 1961-
Copyright date
2016
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 16.06.2016.
Other responsibilities
mentor
Šaranac, Ljiljana
predsednik komisije
Đurić, Zlatko
član komisije
Bjelaković, Bojko
član komisije
Stojanović, Ivana
član komisije
Sajić, Silvija
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za internu medicinu
Alternative title
Estimation of leptin, ghrelin and thyroidal function influences on nutritional status in children and adolescents
Publisher
[M. N. Мiljković]
Format
139 listova
description
Beleška o autoru: list 136
description
Pediatrics, Endocrinology
Abstract (en)
Energy homeostasis is the balance between energy input and expenditure. The neuroendocrine HPT axis has a main significance in this regulation. Anorexigenic (leptin) and orexigen (ghrelin) hormones have a key role in homeostatic regulation by energy intake control.
Research aims: to determine and compare leptin, ghrelin, thyroid hormones and TSH concentrations in examinees with different nutritional status and to examine the correlation of leptin and ghrelin levels with investigated hormones.
The research has been conducted at Clinic for children’s internal medicine in Nis, from January 2014 to February 2015. The prospective study included 88 children: obese, undernourished and control group divided based on BMI-SD.
The results show that body mass at birth in the obese group was statistically significantly higher than in the group of the thin ones. The values of all listed anthropometric parameters have been the highest in the obese group, statistically significant compared to the values of both groups. The values of leptin, leptin/BM and leptin/ghrelin ratio are the highest in the obese group, all statistically significant in comparison to the thin ones. Values for ghrelin, ghrelin/BM and ghrelin/leptin ration are the highest in the thin ones, and the lowest in the obese ones. Except TSH, which is statistically significantly higher in the obese examinees compared to the control and thin group, there are no statistically significant differences between other parameters among groups.
The obtained results point out that, for normal nutritional status, it is necessary to establish these two hormones balance. In this complex regulatory system, involving thyroid hormones, the genetic and environmental factors importance requuires the additional investigations. This is the first study which investigates ghrelin, leptin and thyroid hormones in different nutritional status types of children and adolescents in our country. The results provide better understanding of obesity and undernutrition disorders orexitropic hormonal regulation.
Authors Key words
leptin, ghrelin, childhood obesity, lean children, undernutrition children
Classification
leptin, grelin, gojazna deca, normalno ishranjena, pothranjena
Subject
577.17:616-056.25-053.2(043.3)
Subject
B 007; B 660; B 480
Type
Elektronska teza
Abstract (en)
Energy homeostasis is the balance between energy input and expenditure. The neuroendocrine HPT axis has a main significance in this regulation. Anorexigenic (leptin) and orexigen (ghrelin) hormones have a key role in homeostatic regulation by energy intake control.
Research aims: to determine and compare leptin, ghrelin, thyroid hormones and TSH concentrations in examinees with different nutritional status and to examine the correlation of leptin and ghrelin levels with investigated hormones.
The research has been conducted at Clinic for children’s internal medicine in Nis, from January 2014 to February 2015. The prospective study included 88 children: obese, undernourished and control group divided based on BMI-SD.
The results show that body mass at birth in the obese group was statistically significantly higher than in the group of the thin ones. The values of all listed anthropometric parameters have been the highest in the obese group, statistically significant compared to the values of both groups. The values of leptin, leptin/BM and leptin/ghrelin ratio are the highest in the obese group, all statistically significant in comparison to the thin ones. Values for ghrelin, ghrelin/BM and ghrelin/leptin ration are the highest in the thin ones, and the lowest in the obese ones. Except TSH, which is statistically significantly higher in the obese examinees compared to the control and thin group, there are no statistically significant differences between other parameters among groups.
The obtained results point out that, for normal nutritional status, it is necessary to establish these two hormones balance. In this complex regulatory system, involving thyroid hormones, the genetic and environmental factors importance requuires the additional investigations. This is the first study which investigates ghrelin, leptin and thyroid hormones in different nutritional status types of children and adolescents in our country. The results provide better understanding of obesity and undernutrition disorders orexitropic hormonal regulation.
“Data exchange” service offers individual users metadata transfer in several different formats. Citation formats are offered for transfers in texts as for the transfer into internet pages. Citation formats include permanent links that guarantee access to cited sources. For use are commonly structured metadata schemes : Dublin Core xml and ETUB-MS xml, local adaptation of international ETD-MS scheme intended for use in academic documents.