Title
Značaj oksidativnog stresa i poremećaja metabolizma arginina kao markera metastaziranja tumora debelog creva
Creator
Branković, Branko R. 1967-
Copyright date
2016
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 05.05.2016.
Other responsibilities
mentor
Stanojević, Goran
član komisije
Stojanović, Miroslav
član komisije
Krivokapić, Zoran 1955-
član komisije
Pavlović, Dušica
član komisije
Kocić, Gordana
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za hirurgiju
Alternative title
The importance of oxidative stress and arginine metabolism disorder as markers of colon tumor metastasis
Publisher
[B. R. Beranković]
Format
125 listova
description
Beleška o autoru: listovi 120-121
description
Surgery
Abstract (en)
Colorectal cancer is one of the most frequent human malignant diseases and one of the most common causes of malignant diseases death. Oxidative and nitrosative stress have an important role in cancer initiation and propagation. That is why this study is focused on the determination of oxidative and nitrosative stress markers in tumor, adjacent and health tissue, which are important for estimation of tumor proliferative and angiogenic potential and assessment of their validity in identification of patients’s risk for tumor process promotion and distant metastasis development. The study encompassed 50 patients who underwent surgery due to colorectal cancer. In the tissue samples from resected preparation (tumor, adjacent and healthy tissue, at least 10 cm distant from tumor), oxidative and nitrosative stress markers, malondyaldehyde and nitric oxide (NO), as well as superoxide dismutase activity, were determined. Also, arginase activity and asymmetric (ADMA) and symmetric (SDMA) dimethylarginines, as potent modulators of NO synthesis, were determined. The biochemical parameters were correlated with the tumor recurrence, metastasis and three year- and five year survival. The results of this multidsiciplinary study prove the presence of oxidative stress in tumor tissue. Lower NO concentrations in tumor tissue compared to the adjacent tissue point out high angiogenic potential, which could have clinical importance in the assessment of the probability of local recurrence. Increased ADMA and SDMA concentrations in tumor tissue associated with low NO levels, make the basis for the new therapeutic strategies directed to the use of inhibitors of their synthesis as ideal candidates for molecular threrapy of colorectal cancer. ADMA concentration in adjacent tissue was proved to be an independent predictor of distant metastasis. The obtained results point out that determination of examined biomarkers in colorectal cancer tissue samples, after surgery, could give useful informations about tumor proliferative and angiogenic potential in patients, which could enable individualization of therapy and the choice of adequate adjuvant therapy.
Authors Key words
Karcinom debelog creva, oksidativni stres, L-arginin, azot monoksid, preživljavanje
Authors Key words
Colorectal cancer, oxidative stress, L-arginine, nitric oxid, survival
Classification
616.345-006.6-089:577.122.3(043.3)
Subject
B600
Type
Elektronska teza
Abstract (en)
Colorectal cancer is one of the most frequent human malignant diseases and one of the most common causes of malignant diseases death. Oxidative and nitrosative stress have an important role in cancer initiation and propagation. That is why this study is focused on the determination of oxidative and nitrosative stress markers in tumor, adjacent and health tissue, which are important for estimation of tumor proliferative and angiogenic potential and assessment of their validity in identification of patients’s risk for tumor process promotion and distant metastasis development. The study encompassed 50 patients who underwent surgery due to colorectal cancer. In the tissue samples from resected preparation (tumor, adjacent and healthy tissue, at least 10 cm distant from tumor), oxidative and nitrosative stress markers, malondyaldehyde and nitric oxide (NO), as well as superoxide dismutase activity, were determined. Also, arginase activity and asymmetric (ADMA) and symmetric (SDMA) dimethylarginines, as potent modulators of NO synthesis, were determined. The biochemical parameters were correlated with the tumor recurrence, metastasis and three year- and five year survival. The results of this multidsiciplinary study prove the presence of oxidative stress in tumor tissue. Lower NO concentrations in tumor tissue compared to the adjacent tissue point out high angiogenic potential, which could have clinical importance in the assessment of the probability of local recurrence. Increased ADMA and SDMA concentrations in tumor tissue associated with low NO levels, make the basis for the new therapeutic strategies directed to the use of inhibitors of their synthesis as ideal candidates for molecular threrapy of colorectal cancer. ADMA concentration in adjacent tissue was proved to be an independent predictor of distant metastasis. The obtained results point out that determination of examined biomarkers in colorectal cancer tissue samples, after surgery, could give useful informations about tumor proliferative and angiogenic potential in patients, which could enable individualization of therapy and the choice of adequate adjuvant therapy.
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