Title
Stepen oštećenja jetre kod neoadjuvantne terapije metastatskog kolorektalnog karcinoma
Creator
Pecić, Vanja M. 1973-
Copyright date
2016
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 26.09.2016.
Other responsibilities
mentor
Stojanović, Miroslav
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za radiologiju, nuklearnu medicinu i osnovi kliničke onkologije
Alternative title
The degree of liver damage in neoadjuvant treatmant of metastatic colorectal cancer
Publisher
[V. М. Pecić]
Format
114 listova
description
Prilog: listovi 112-114
description
Citology, oncology, cancerology
Abstract (en)
The study included 90 patients operated for colorectal cancer with liver metastases, divided into three groups. In the first group (G1) were patients who received FOLFOX IV neoadjuvant therapy, while in the second group (G2) biological agent bevacizumab was added to FOLFOX IV. The third group was the control group without chemotherapy. Biochemical parameters of metabolic syndrome (MS) and liver damage were followed. Liver steatosis and sinusoidal obstructive syndrome (SOS) were assesed by pathohystological examination. Steatosis liver injury in pathohystology was found in 56.7 % of patients in G1, 3.3 % in G2 and in 40% in the control group. Independent risk factors for degree of statosis were triglycerides, HDL and BMI. MS was present in 75% of patients in G1, which was significantly higher in comparison to G2 (27%). SOS was registered in 66.7 % in G2, 6.7 % in G1, while it was not registered in the control group. Independent risk factors for liver SOS were the following parameters of MS: triglycerides and HDL.
Authors Key words
kolorektalni karcinom, metastaze u jetri, neoadjuvantna terapija
Authors Key words
colorectal cancer, liver metastasis, neoadjuvant therapy
Classification
616.348/.35-006.6-085.277:616.36(043.3)
Subject
B 200
Type
Elektronska teza
Abstract (en)
The study included 90 patients operated for colorectal cancer with liver metastases, divided into three groups. In the first group (G1) were patients who received FOLFOX IV neoadjuvant therapy, while in the second group (G2) biological agent bevacizumab was added to FOLFOX IV. The third group was the control group without chemotherapy. Biochemical parameters of metabolic syndrome (MS) and liver damage were followed. Liver steatosis and sinusoidal obstructive syndrome (SOS) were assesed by pathohystological examination. Steatosis liver injury in pathohystology was found in 56.7 % of patients in G1, 3.3 % in G2 and in 40% in the control group. Independent risk factors for degree of statosis were triglycerides, HDL and BMI. MS was present in 75% of patients in G1, which was significantly higher in comparison to G2 (27%). SOS was registered in 66.7 % in G2, 6.7 % in G1, while it was not registered in the control group. Independent risk factors for liver SOS were the following parameters of MS: triglycerides and HDL.
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