Title
Morfometrijska i imunohistohemijska analiza udruženosti strukturnih promena sa distribucijom psamoma telašaca u horoidnim pleksusima moždanih komora tokom starenja čoveka
Creator
Živković, Vladimir S., 1973-
Copyright date
2016
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 13.09.2016.
Other responsibilities
mentor
Čukuranović, Rade
član komisije
Jovanović, Ivan 1970-
član komisije
Filipović, Branislav 1962-
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za anatomiju
Alternative title
Morphometric and immunohistochemic analysis of structural changes in relation to psamomma bodies distribution in cerebral ventricules' choroid plexus with age in humans
Publisher
[Vladimir S. Živković]
Format
203 str.
description
Beleška o autoru: str. 203
description
Anatomy
Abstract (en)
During the ageing process, numerous structural and functional changes occur in the cerebral ventricles’ choroid plexus. The formation of psamomma bodies starts at an early age, and is considered a physiological consequence of the ageing process.
Using histochemical and immunohistochemical methods, autopsy samples of choroid plexus of all four cerebral ventricles were analyzed morphologically and morphometrically. The structure of the choroid plexus, its epithelium morphology, as well as the distribution and characteristics of the psamommma bodies, were investigated in this study. Besides, the expression of CD44, CD68, osteopontin and osteocalcin, was analyzed.
The results of this study showed significant structural changes in choroid plexus during ageing. Choroid plexus arborification and its blood vessels density is reduced. The epitelium changed with presence of high domed, flattened spindle, or large cells expanded by its content. Psamomma bodies in the elderly formed large groups, often inside cysts, and showed an increse in their number and size. Increased osteopontin expression is characteristic younger population choroid plexus, unlike osteocalcin whose expression progressively increases withe age. Psamomma bodies formation and their characteristics are in correlation with changes in the structure of the choroid plexus and its epithelium, during the ageing process in humans.
After taking into consideration the role of choroid plexus in the central nervous system homeostasis regulation, the stated changes in ageing choroid plexus and psamomma bodies characteristics, may contribute to the reveiling of the mechanism of fuctional impairement of the brain in the elderly.
Authors Key words
psamomatozna telašca, horoidni pleksus, starenje, histohemija, imunohistohemija, morfometrija, CD44, CD68, osteopontin, osteokalcin
Authors Key words
psamomma bodies, choroid plexus, ageing, histochemistry, immunohistochemistry, morphometry, CD44, CD68, osteopontin, osteocalcin
Classification
611.018.8:577.24(043.3)
Subject
B440
Type
Elektronska teza
Abstract (en)
During the ageing process, numerous structural and functional changes occur in the cerebral ventricles’ choroid plexus. The formation of psamomma bodies starts at an early age, and is considered a physiological consequence of the ageing process.
Using histochemical and immunohistochemical methods, autopsy samples of choroid plexus of all four cerebral ventricles were analyzed morphologically and morphometrically. The structure of the choroid plexus, its epithelium morphology, as well as the distribution and characteristics of the psamommma bodies, were investigated in this study. Besides, the expression of CD44, CD68, osteopontin and osteocalcin, was analyzed.
The results of this study showed significant structural changes in choroid plexus during ageing. Choroid plexus arborification and its blood vessels density is reduced. The epitelium changed with presence of high domed, flattened spindle, or large cells expanded by its content. Psamomma bodies in the elderly formed large groups, often inside cysts, and showed an increse in their number and size. Increased osteopontin expression is characteristic younger population choroid plexus, unlike osteocalcin whose expression progressively increases withe age. Psamomma bodies formation and their characteristics are in correlation with changes in the structure of the choroid plexus and its epithelium, during the ageing process in humans.
After taking into consideration the role of choroid plexus in the central nervous system homeostasis regulation, the stated changes in ageing choroid plexus and psamomma bodies characteristics, may contribute to the reveiling of the mechanism of fuctional impairement of the brain in the elderly.
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