Title
Korelacija mape difuznog keficijenta i difuzije sa stepenom maligniteta glijalnih tumora
Creator
Ignjatović, Jelena 1978-
Copyright date
2015
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
Dozvoljavate samo preuzimanje i distribuciju dela, ako/dok se pravilno naznačava ime autora, bez ikakvih promena dela i bez prava komercijalnog korišćenja dela. Ova licenca je najstroža CC licenca. Osnovni opis Licence: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/deed.sr_LATN. Sadržaj ugovora u celini: http://creativecommons.org/licenses/by-nc-nd/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
description
Datum odbrane: 06.04.2015.
Other responsibilities
mentor
Stojanov, Dragan
član komisije
Stojanović, Nebojša
član komisije
Stošić-Opinćal, Tatjana 1958-
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za radiologiju, nuklearnu medicinu i osnovi kliničke onkologije
Alternative title
Correlation of the maps of the coefficient of diffusion and diffusion with grades of malignancy of glial tumors
Publisher
[J. S. Ignjatović]
Format
92 lista
description
Radiology
Abstract (en)
First application of magnetic resonance imaging (MRI) in the early 1980s radically changed the radiographic diagnosis of primary and secondary brain tumors. MRI is a key modality not only for lesion diagnosis, but also to evaluate the extension, type and grade of the tumor. Advanced MRI techniques such as diffusion weighted imaging (DWI) provide physiologic information that complements the anatomic information available with conventional MRI. The utility of DWI and apparent diffusion coefficients (ADC) mapping is in the preoperative diagnosis of brain tumors with respect to assessing cellularity or grade; distinguishing enhancing from non-enhancing areas, tumor from perifocal vasogenic edema, or viable tumor from necrosis; or predicting tumor response to treatment. Study results qualify ADC coefficient as an important quantitative marker of glioma as evidenced by the fact that the value of ADC is inversely proportional to the degree of the tumor cellularity and tumor grade. The high values of ADC correspond to low grade gliomas, necrosis, cysts, while on the other hand, small values of ADC depict density, high cellularity and high grade malignant changes. The ADC has been found to have an inverse relation with the WHO grade of astrocytomas. Lower ADC values suggest a malignant high-grade gliomas, whereas higher ADCs suggest low-grade gliomas. The paper stresses that ADC is of great importance in clinical practice, in tumor behavior monitoring, in precious view of tumor response to standardized protocols, then this radiological ratio also has a valuable prognostic significance after surgical treatment and postoperative radiotherapy because there is a connection between the ADC values and survival time in patients with glioblastoma. The ADC values can be considered as predictive biomarker for the anti-angiogenesis treatment of malignant gliomas. ADC values show variation (increase) within vasogenic edema which monitors high and low grade gliomas, metastatic tumors, as a consequence of increased extracellular fluid. The values of ADC of high grades gliomas were significantly lower than the vales of ADC of metastases. To summarize, DWI can be complementary but very reliable imaging method not only for the diagnosis and surgical treatment of glioma grade, but also for successful monitoring of tumor recurrence and tumor response to treatment.
Authors Key words
magnetna rezonanca, difuzija, difuzioni koeficijent, glijalni tumori
Authors Key words
magnetic resonance, difusion, apparent diffusion coefficients, glial tumors
Classification
616-073.7:616.831-006.48(043.3)
Type
Tekst
Abstract (en)
First application of magnetic resonance imaging (MRI) in the early 1980s radically changed the radiographic diagnosis of primary and secondary brain tumors. MRI is a key modality not only for lesion diagnosis, but also to evaluate the extension, type and grade of the tumor. Advanced MRI techniques such as diffusion weighted imaging (DWI) provide physiologic information that complements the anatomic information available with conventional MRI. The utility of DWI and apparent diffusion coefficients (ADC) mapping is in the preoperative diagnosis of brain tumors with respect to assessing cellularity or grade; distinguishing enhancing from non-enhancing areas, tumor from perifocal vasogenic edema, or viable tumor from necrosis; or predicting tumor response to treatment. Study results qualify ADC coefficient as an important quantitative marker of glioma as evidenced by the fact that the value of ADC is inversely proportional to the degree of the tumor cellularity and tumor grade. The high values of ADC correspond to low grade gliomas, necrosis, cysts, while on the other hand, small values of ADC depict density, high cellularity and high grade malignant changes. The ADC has been found to have an inverse relation with the WHO grade of astrocytomas. Lower ADC values suggest a malignant high-grade gliomas, whereas higher ADCs suggest low-grade gliomas. The paper stresses that ADC is of great importance in clinical practice, in tumor behavior monitoring, in precious view of tumor response to standardized protocols, then this radiological ratio also has a valuable prognostic significance after surgical treatment and postoperative radiotherapy because there is a connection between the ADC values and survival time in patients with glioblastoma. The ADC values can be considered as predictive biomarker for the anti-angiogenesis treatment of malignant gliomas. ADC values show variation (increase) within vasogenic edema which monitors high and low grade gliomas, metastatic tumors, as a consequence of increased extracellular fluid. The values of ADC of high grades gliomas were significantly lower than the vales of ADC of metastases. To summarize, DWI can be complementary but very reliable imaging method not only for the diagnosis and surgical treatment of glioma grade, but also for successful monitoring of tumor recurrence and tumor response to treatment.
“Data exchange” service offers individual users metadata transfer in several different formats. Citation formats are offered for transfers in texts as for the transfer into internet pages. Citation formats include permanent links that guarantee access to cited sources. For use are commonly structured metadata schemes : Dublin Core xml and ETUB-MS xml, local adaptation of international ETD-MS scheme intended for use in academic documents.