Title
Sinteza i karakterizacija alicina, njegovih derivata i inkluzionih kompleksa : doktorska disertacija
Creator
Nikolić, Vesna D.
Copyright date
2003
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
Other responsibilities
mentor
Stanković, Mihajlo
član komisije
Cvetković, Dragan
član komisije
Palić, Radosav
član komisije
Kapor, Agneš
član komisije
Cekić, Milorad
Academic Expertise
Tehničko-tehnološke nauke
University
Univerzitet u Nišu
Faculty
Tehnološki fakultet
Group
Katedra za hemijske nauke
Publisher
Leskovac : [V. Nikolić]
Format
PDF/A (141 list)
description
Umnoženo za odbranu.
Unverzitet u Nišu, Tehnološki fakultet u Leskovcu., 2003,
Izvod ; Abstract.
Bibliografija: listovi 117-120.
Abstract (en)
The main carriers of the pharmacological activity of garlic (Allium sativum L.)
are organosulfur compounds, the most important being allicin (diallyl
thiosulfinate). Allicin has a wide range of antibacterial and antifungal effects.
It shows significant antioxidative and antitumor effect. The organic molecule
is very unstable and depending on the external factors it is transformed to
pharmacologically active derivatives. The most important pharmacologically
active allicin derivatives are ajoenes and vinyldithiins. They take part in the
inhibition of the thrombocyte aggregation, in the regulation of systolic and
diastolic blood pressure, reduce the triglyceride and phospholipid levels, show
diuretic, antimicrobial, fibrinolytic and vasodilative effect. Therefore, they are of great importance for the pharmaceutical industry.
In this dissertation the kinetics of synthesis were studied, the optimal kinetic
parameters determined, and defined the mechanism of synthesis of allicin and
its derivatives. For their stabilization, allicin complexes were synthesized
with β-cyclodextrin and urea as inclusion complexes. The physical and
chemical characterization of the synthesized compounds was done by up to
date analysis methods. The microbiological studies results were used to
determine the microbiological activities of the synthesized compounds.
The results obtained in this dissertation present a scientific contribution to the research of new pharmacologically active compounds that might, in the near
future, find significant application in the pharmaceutical industry.
Authors Key words
allicin, ajoene, vinyldithiin, molecule inclusion complexes, β-cyclodextrin,
urea, microbiological studies, kinetics, kinetic parameters, mechanism of
synthesis
Type
Elektronska teza
Abstract (en)
The main carriers of the pharmacological activity of garlic (Allium sativum L.)
are organosulfur compounds, the most important being allicin (diallyl
thiosulfinate). Allicin has a wide range of antibacterial and antifungal effects.
It shows significant antioxidative and antitumor effect. The organic molecule
is very unstable and depending on the external factors it is transformed to
pharmacologically active derivatives. The most important pharmacologically
active allicin derivatives are ajoenes and vinyldithiins. They take part in the
inhibition of the thrombocyte aggregation, in the regulation of systolic and
diastolic blood pressure, reduce the triglyceride and phospholipid levels, show
diuretic, antimicrobial, fibrinolytic and vasodilative effect. Therefore, they are of great importance for the pharmaceutical industry.
In this dissertation the kinetics of synthesis were studied, the optimal kinetic
parameters determined, and defined the mechanism of synthesis of allicin and
its derivatives. For their stabilization, allicin complexes were synthesized
with β-cyclodextrin and urea as inclusion complexes. The physical and
chemical characterization of the synthesized compounds was done by up to
date analysis methods. The microbiological studies results were used to
determine the microbiological activities of the synthesized compounds.
The results obtained in this dissertation present a scientific contribution to the research of new pharmacologically active compounds that might, in the near
future, find significant application in the pharmaceutical industry.
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