Title
Morfometrijska i imunohistohemijska analiza struktura adenohipofize uključenih u sistem hipotalamo-hipofizno-adrenalne osovine tokom starenja čoveka : doktorska disertacija
Creator
Ljubomirović, Miljana N. 1980-
Copyright date
2014
Object Links
Select license
Autorstvo-Nekomercijalno 3.0 Srbija (CC BY-NC 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
Other responsibilities
mentor
Jovanović, Ivan
član komisije
Čukuranović, Rade
član komisije
Ugrenović, Slađana
član komisije
Stefanović, Natalija
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za anatomiju
Title translated
MORPHOMETRIC AND IMMUNOHISTOCHEMICAL ANALYSIS OF THE ADENOHYPOPHYSIS STRUCTURES
INVOLVED IN THE SYSTEM OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS DURING THE AGING PROCESS
Publisher
Niš : [M. N. Ljubomirović]
Format
PDF/A (120 listova)
description
Umnoženo za odbranu.
Univerzitet u Nišu, Medicinski fakultet, 2014.
Bibliografija: listovi 93-104.
Abstract (en)
The aging in men is accompanied by an increase in the presence of connective tissue
in all the organs and tissues, and with increase of corticotrophs and folliculostellate cells in
adenohypophysis, which can affect the function of the HPA axis in healthy elderly
individuals.
Objective of the research was to perform quantification of structural changes during
aging (cellularity, presence of the connective tissue and blood flow), collagen type IV,
corticotrophs and folliculostellate cells on the pituitary tissue, obtained at autopsy, using
histochemical, immunohistochemical and morphometric methods.
Histochemical part of the research showed an increase of the cell size that occured
during normal aging in the adenohypophysis. The analyzed cells of the adenohypophysis
were significantly larger and, at the same time, they were characterized by a substantially
more regular shape in female in comparison to the male patients cases. Differences in the
cellular composition of the pituitary tissue were observed in cases of the opposite sex and
the significant higher number of basophils in males was noted. Hypertrophy of the cells
was accompanied by proliferation of the pituitary connective tissue, as well as by it’s
poarer vascularization during aging.
Results of the immunohistochemical part of the study confirmed that there was an
increase in the average volume densities of the folliculostellate cells and corticotrophs. The
increase in the presence of type IV collagen was also present and the obtained result is
consistent to statistically significant increase in the presence of the connective tissue in the
adenohypophysis during the aging process, which we observed in the histochemical part of
our study.
Authors Key words
Adenohipofiza, adenohipofiza, hipofiza, HPA osovina, starenje
Authors Key words
adenohypophysis, pituitary gland, HPA axis, aging
Subject
611
Subject
612
Type
Elektronska teza
Abstract (en)
The aging in men is accompanied by an increase in the presence of connective tissue
in all the organs and tissues, and with increase of corticotrophs and folliculostellate cells in
adenohypophysis, which can affect the function of the HPA axis in healthy elderly
individuals.
Objective of the research was to perform quantification of structural changes during
aging (cellularity, presence of the connective tissue and blood flow), collagen type IV,
corticotrophs and folliculostellate cells on the pituitary tissue, obtained at autopsy, using
histochemical, immunohistochemical and morphometric methods.
Histochemical part of the research showed an increase of the cell size that occured
during normal aging in the adenohypophysis. The analyzed cells of the adenohypophysis
were significantly larger and, at the same time, they were characterized by a substantially
more regular shape in female in comparison to the male patients cases. Differences in the
cellular composition of the pituitary tissue were observed in cases of the opposite sex and
the significant higher number of basophils in males was noted. Hypertrophy of the cells
was accompanied by proliferation of the pituitary connective tissue, as well as by it’s
poarer vascularization during aging.
Results of the immunohistochemical part of the study confirmed that there was an
increase in the average volume densities of the folliculostellate cells and corticotrophs. The
increase in the presence of type IV collagen was also present and the obtained result is
consistent to statistically significant increase in the presence of the connective tissue in the
adenohypophysis during the aging process, which we observed in the histochemical part of
our study.
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