Title
Dijagnostički i prognostički značaj serumskog amiloida A, prokalcitonina i D-dimera kod bolesnika sa vanbolnički stečenom pneumonijom : doktorska disertacija
Creator
Nastasijević Borovac, Desa B. 1971-
Copyright date
2014
Object Links
Select license
Autorstvo 3.0 Srbija (CC BY 3.0)
License description
Dozvoljavate umnožavanje, distribuciju i javno saopštavanje dela, i prerade, ako se navede ime autora na način odredjen od strane autora ili davaoca licence, čak i u komercijalne svrhe. Ovo je najslobodnija od svih licenci. Osnovni opis Licence: http://creativecommons.org/licenses/by/3.0/rs/deed.sr_LATN Sadržaj ugovora u celini: http://creativecommons.org/licenses/by/3.0/rs/legalcode.sr-Latn
Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
Other responsibilities
mentor
Pejčić, Tatjana
član komisije
Stanković, Ivana
član komisije
Rančić, Milan
član komisije
Đorđević, Vidosava
član komisije
Lazić, Zorica
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za internu medicinu
Title translated
DIAGNOSTIC AND PROGNOSTIC ROLE OF
SERUM AMILOID A, PROCALCITONIN AND D-DIMER
IN PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA
Publisher
Niš : [D. B. Nastasijević Borovac]
Format
PDF/A (177 listova)
description
Umnoženo za odbranu.
Univerzitet u Nišu, Medicinski fakultet., 2014.
Bibliografija: listovi 130-160.
Biografija: list 163.
Sažetak ; Summary.
Abstract (en)
Severity assessment is a crucial component in the management of patients with community-acquired pneumonia (CAP). Recommended Pneumonia Severity Index (PSI) is an accurate predicting model, but not so easily applicable in clinical practice. The aim of the study was to determine whether some biomarkers of inflammation and coagulation, correlate with severity of CAP and can predict mortality risk better than standard biomarkers and recommended PSI.
The study included 129 patients with CAP, an overall median age of 64.83 ± 13.32 y (77 males and 52 females). There were 55 (43.63%) patients with severe CAP. We were found a good linear correlation between severity of CAP and procalcitonin (r = 0.427; p < 0.001) and between D dimer (r = 0.5106; p < 0.0001). Serum amiloid A, WBC and CRP have poor linear correlation. In diagnosis of severe CAP best diagnostic value have procalcitonin (AUC = 0.813) and D-dimer (AUC = 0.789). Thirteen patients were died (10.7%), and 16 patients have complications (12.4%). In predicting of mortality risk PSI for cut of > PSI III showed sensitivity of 0.92, specificity 0.62 and AUC 0.868. Serum amiloid A, WBC and CRP were not in correlation with the risk of mortality. In non surviving patients D-dimer (2498.38 ng/mL) and procalcitonin (3.14 ng/mL) were significantly higher than in surviving patients. In predicting mortality risk, D-dimer (cut of >1538 ng/mL) showed sensitivity 0.84, specificity 0.86 and AUC 0.859. Procalcitonin, for cut of value > 0.93 ng/mL, in predicting of mortality risk showed sensitivity of 1.0, specifity of 0.64 and AUC 0.844. There was no statistical difference between AUC of PSI and D-dimer (p = 0.9005), and PSI and procalcitonin (p = 0.6135) in predicting mortality risk.
This study pointed out that: serum amilod A correlates poor with severity of disease; and that high D-dimer and procalcitonin level correlate with severity of disease (better than CRP and WBC) and mortality risk (similar as recommended PSI). D-dimer and procalcitonin could be useful biomarkers for predicting severity of disease and clinical outcome in patients with CAP.
Authors Key words
Vanbolničke pneumonije, prokalcitonin, serumski amiloid A, D-dimer, vanbolnički stečena pneumonija
Authors Key words
procalcitonin, serum amiloid A, D-dimer, community acquired pneumonia
Subject
616
Type
Elektronska teza
Abstract (en)
Severity assessment is a crucial component in the management of patients with community-acquired pneumonia (CAP). Recommended Pneumonia Severity Index (PSI) is an accurate predicting model, but not so easily applicable in clinical practice. The aim of the study was to determine whether some biomarkers of inflammation and coagulation, correlate with severity of CAP and can predict mortality risk better than standard biomarkers and recommended PSI.
The study included 129 patients with CAP, an overall median age of 64.83 ± 13.32 y (77 males and 52 females). There were 55 (43.63%) patients with severe CAP. We were found a good linear correlation between severity of CAP and procalcitonin (r = 0.427; p < 0.001) and between D dimer (r = 0.5106; p < 0.0001). Serum amiloid A, WBC and CRP have poor linear correlation. In diagnosis of severe CAP best diagnostic value have procalcitonin (AUC = 0.813) and D-dimer (AUC = 0.789). Thirteen patients were died (10.7%), and 16 patients have complications (12.4%). In predicting of mortality risk PSI for cut of > PSI III showed sensitivity of 0.92, specificity 0.62 and AUC 0.868. Serum amiloid A, WBC and CRP were not in correlation with the risk of mortality. In non surviving patients D-dimer (2498.38 ng/mL) and procalcitonin (3.14 ng/mL) were significantly higher than in surviving patients. In predicting mortality risk, D-dimer (cut of >1538 ng/mL) showed sensitivity 0.84, specificity 0.86 and AUC 0.859. Procalcitonin, for cut of value > 0.93 ng/mL, in predicting of mortality risk showed sensitivity of 1.0, specifity of 0.64 and AUC 0.844. There was no statistical difference between AUC of PSI and D-dimer (p = 0.9005), and PSI and procalcitonin (p = 0.6135) in predicting mortality risk.
This study pointed out that: serum amilod A correlates poor with severity of disease; and that high D-dimer and procalcitonin level correlate with severity of disease (better than CRP and WBC) and mortality risk (similar as recommended PSI). D-dimer and procalcitonin could be useful biomarkers for predicting severity of disease and clinical outcome in patients with CAP.
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