Title
Značaj kliničkih i biohemijskih parametara za tok, prognozu i kvalitet života bolesnika sa sistemskim eritemskim lupusom : doktorska disertacija
Creator
Živković, Valentina 1965-
Copyright date
2013
Object Links
Select license
Autorstvo-Nekomercijalno-Bez prerade 3.0 Srbija (CC BY-NC-ND 3.0)
License description
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Language
Serbian
Cobiss-ID
Theses Type
Doktorska disertacija
Other responsibilities
mentor
Stanković, Aleksandra
član komisije
Cvetković, Tatjana 1965-
član komisije
Vujasinović-Stupar, Nada 1955-
Academic Expertise
Medicinske nauke
University
Univerzitet u Nišu
Faculty
Medicinski fakultet
Group
Katedra za socijalnu medicinu i higijenu sa medicinskom ekologijom
Title translated
The Significance of Clinical and Biochemical Parameters for the Course, Prognosis, and
Quality of Life of Patients with Systemic Lupus Erythematosus
Publisher
Niš : [V. Živković]
Format
PDF/A (163 lista)
description
Umnoženo za odbranu.
Univerzitet u Nišu, Medicinski fakultet, 2013.
Bibliografija: listovi 120-133.
Biografija: list [152]
Sažetak ; Summary.
Abstract (en)
Successful treatment and control of SLE requires precise assessment of disease
activity and quality of life, as well as determination of biologic markers in order to administer
proper therapy, to achieve disease remission, or to prevent or delay damage to the involved
organs and treatment complications.
This paper aimed to assess disease activity, degree of organ damage, and quality of life
of SLE patients, using appropriate questionnaires and establishing their correlation; to
determine the prevalence, specificity, and sensitivity of anti-nucleosome antibodies, anti-C1q
antibodies, and serum and urinary monocyte chemoattractant protein-1 (MCP-1), and to
identify their possible association with active forms of SLE and lupus nephritis.
The studied group comprised 85 SLE patients, while 30 healthy examinees comprised
the control group. In all examinees, in addition to standard clinical examination and
supplementary diagnostic procedures, the levels of anti-nucleosome antibodies, anti-C1q
antibodies, and serum and urinary MCP-1 were determined by way of the ELISA method.
Disease activity was also assessed using the SLEDAI, ECLAM, and LAI questionnaires and
by way of global physician assessment; organ damage was assessed using the SDI damage
index, quality of life was assessed using the SF-36 questionnaire, and fatigue severity was
measured using the FSS fatigue scale.
Based on the completed study, a conclusion may be drawn that disease activity did not
correlate with organ damage, quality of life, and fatigue severity. Anti-C1q antibodies and
simultaneous positivity of anti-nucleosome, anti-C1q and anti-dsDNA antibodies were
associated with lupus nephritis activity. Urinary MCP-1 demonstrated a highest association
with active lupus nephritis forms, being in high positive correlation with the degree of
proteinuria and in negative correlation with glomerular filtration rate.
Authors Key words
Sistemski eritemski lupus,
anti-C1q antitela, anti-nukleozomska antitela, monocitni hemoatraktant protein-1, lupusni nefritis
Authors Key words
anti-C1q antibodies, anti-nucleosome antibodies, monocyte chemoattractant protein-1, lupus nephritis, systemic lupus erythematosus
Subject
616
Type
Elektronska teza
Abstract (en)
Successful treatment and control of SLE requires precise assessment of disease
activity and quality of life, as well as determination of biologic markers in order to administer
proper therapy, to achieve disease remission, or to prevent or delay damage to the involved
organs and treatment complications.
This paper aimed to assess disease activity, degree of organ damage, and quality of life
of SLE patients, using appropriate questionnaires and establishing their correlation; to
determine the prevalence, specificity, and sensitivity of anti-nucleosome antibodies, anti-C1q
antibodies, and serum and urinary monocyte chemoattractant protein-1 (MCP-1), and to
identify their possible association with active forms of SLE and lupus nephritis.
The studied group comprised 85 SLE patients, while 30 healthy examinees comprised
the control group. In all examinees, in addition to standard clinical examination and
supplementary diagnostic procedures, the levels of anti-nucleosome antibodies, anti-C1q
antibodies, and serum and urinary MCP-1 were determined by way of the ELISA method.
Disease activity was also assessed using the SLEDAI, ECLAM, and LAI questionnaires and
by way of global physician assessment; organ damage was assessed using the SDI damage
index, quality of life was assessed using the SF-36 questionnaire, and fatigue severity was
measured using the FSS fatigue scale.
Based on the completed study, a conclusion may be drawn that disease activity did not
correlate with organ damage, quality of life, and fatigue severity. Anti-C1q antibodies and
simultaneous positivity of anti-nucleosome, anti-C1q and anti-dsDNA antibodies were
associated with lupus nephritis activity. Urinary MCP-1 demonstrated a highest association
with active lupus nephritis forms, being in high positive correlation with the degree of
proteinuria and in negative correlation with glomerular filtration rate.
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